TY - JOUR
T1 - Short-term exposure to carbamazepine causes oxidative stress on common carp (Cyprinus carpio)
AU - Gasca-Pérez, Eloy
AU - Galar-Martínez, Marcela
AU - García-Medina, Sandra
AU - Pérez-Coyotl, Isabel A.
AU - Ruiz-Lara, Karina
AU - Cano-Viveros, Selene
AU - Pérez-Pastén Borja, Ricardo
AU - Gómez-Oliván, Leobardo M.
N1 - Publisher Copyright:
© 2018
PY - 2019/2
Y1 - 2019/2
N2 - The aim of this research was to determine the bioconcentration factor and if subacute exposure to carbamazepine (2 mg L −1 ) modifies the oxidative state of liver, gills and brain of Cyprinus carpio. This was measured through the following biomarkers: hydroperoxide and protein carbonyl content, lipid peroxidation degree, as well as superoxide dismutase, catalase and glutathione peroxidase activity. Carbamazepine concentration in carp's tissue was also determined by liquid chromatography with a diode arrangement detector. An increase in lipid peroxidation degree, hydroperoxide and protein carbonyl content, and a decrease in the activity of the antioxidant enzymes (P < 0.05) with respect to control was observed. Also, there is an increase in the concentration of carbamazepina present in the organs with respect to the water in the system, which denotes bioconcentration of the drug. In conclusion, carbamazepine is bioconcentrated and produces oxidative stress on the common carp (C. carpio).
AB - The aim of this research was to determine the bioconcentration factor and if subacute exposure to carbamazepine (2 mg L −1 ) modifies the oxidative state of liver, gills and brain of Cyprinus carpio. This was measured through the following biomarkers: hydroperoxide and protein carbonyl content, lipid peroxidation degree, as well as superoxide dismutase, catalase and glutathione peroxidase activity. Carbamazepine concentration in carp's tissue was also determined by liquid chromatography with a diode arrangement detector. An increase in lipid peroxidation degree, hydroperoxide and protein carbonyl content, and a decrease in the activity of the antioxidant enzymes (P < 0.05) with respect to control was observed. Also, there is an increase in the concentration of carbamazepina present in the organs with respect to the water in the system, which denotes bioconcentration of the drug. In conclusion, carbamazepine is bioconcentrated and produces oxidative stress on the common carp (C. carpio).
KW - Anticonvulsant
KW - Bioconcentration
KW - Biomarkers
KW - Neuroactive compound
KW - Oxidative status
UR - http://www.scopus.com/inward/record.url?scp=85059673777&partnerID=8YFLogxK
U2 - 10.1016/j.etap.2018.12.017
DO - 10.1016/j.etap.2018.12.017
M3 - Artículo
C2 - 30639901
SN - 1382-6689
VL - 66
SP - 96
EP - 103
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
ER -