Quinoid systems in chemistry and pharmacology

Julio López; Fabiola De La Cruz; Yolanda Alcaraz; Francisco Delgado; Miguel A. Vázquez

doi:10.1007/s00044-015-1412-y

Quinoid systems in chemistry and pharmacology

Julio López, Fabiola De La Cruz, Yolanda Alcaraz, Francisco Delgado, Miguel A. Vázquez

Escuela Nacional de Ciencias Biológicas (ENCB)

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

In this paper, we present a brief review of quinoid systems, focusing on their chemical synthesis over the last decade. We address not only major methods of synthesizing quinoids, but also their involvement in biological processes. We highlight their medical relevance and versatility, including antitumor, antiretroviral, or antihypertensive agents, properties determined by their various patterns of substitution. Graphical Abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	3599-3620
Number of pages	22
Journal	Medicinal Chemistry Research
Volume	24
Issue number	10
DOIs	https://doi.org/10.1007/s00044-015-1412-y
State	Published - 31 Oct 2015

Keywords

Cytotoxicity
Natural products
Pharmacology
Quinone
Redox
Synthesis

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AU - López, Julio

AU - De La Cruz, Fabiola

AU - Alcaraz, Yolanda

AU - Delgado, Francisco

AU - Vázquez, Miguel A.

PY - 2015/10/31

Y1 - 2015/10/31

N2 - In this paper, we present a brief review of quinoid systems, focusing on their chemical synthesis over the last decade. We address not only major methods of synthesizing quinoids, but also their involvement in biological processes. We highlight their medical relevance and versatility, including antitumor, antiretroviral, or antihypertensive agents, properties determined by their various patterns of substitution. Graphical Abstract: [Figure not available: see fulltext.]

AB - In this paper, we present a brief review of quinoid systems, focusing on their chemical synthesis over the last decade. We address not only major methods of synthesizing quinoids, but also their involvement in biological processes. We highlight their medical relevance and versatility, including antitumor, antiretroviral, or antihypertensive agents, properties determined by their various patterns of substitution. Graphical Abstract: [Figure not available: see fulltext.]

KW - Cytotoxicity

KW - Natural products

KW - Pharmacology

KW - Quinone

KW - Redox

KW - Synthesis

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DO - 10.1007/s00044-015-1412-y

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JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

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Quinoid systems in chemistry and pharmacology

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Keywords

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