Probable efecto hepatoprotector de la verbena en la hepatitis inducida con tetracloruro de carbono en la rata

Liliana Favari-Perozzi; Raquel Nava-Álvarez; Ma Estela Meléndez-Camargo

Probable efecto hepatoprotector de la verbena en la hepatitis inducida con tetracloruro de carbono en la rata

Translated title of the contribution: Possible protective effect of verbena in rat liver injury induced by carbon tetrachloride

Liliana Favari-Perozzi, Raquel Nava-Álvarez, Ma Estela Meléndez-Camargo

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Verbena Carolina known as verbena is used in the Mexican folk medicine for the biliary diseases. The purpose of this study was to evaluate the hepatoprotective effects of verbena on the acute intoxication of CCl₄ in female Wistar rats. The animals were protected with verbena and colchicine (positive control) orally for seven days and CCl₄ was given ip (2.5 mL kg^-1) on day 8. CCl₄-induced the increase of serum activities of gamma-glutamyl transpeptidase, alanine aminotransferase and alkaline phosphatase, bilirubin and MDA concentrations but decreased the hepatic glycogen. Verbena just partially protected the increase of γGT. Colchicine partially protected all the biomarkers studied. No changes in sleeping time were observed in CCl₄-treated rats. The LD₅₀ was higher than 30 mg kg^-1.

Translated title of the contribution	Possible protective effect of verbena in rat liver injury induced by carbon tetrachloride
Original language	Spanish
Pages (from-to)	19-25
Number of pages	7
Journal	Revista Mexicana de Ciencias Farmaceuticas
Volume	38
Issue number	3
State	Published - Jul 2007
Externally published	Yes

Cite this

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title = "Probable efecto hepatoprotector de la verbena en la hepatitis inducida con tetracloruro de carbono en la rata",

abstract = "Verbena Carolina known as verbena is used in the Mexican folk medicine for the biliary diseases. The purpose of this study was to evaluate the hepatoprotective effects of verbena on the acute intoxication of CCl4 in female Wistar rats. The animals were protected with verbena and colchicine (positive control) orally for seven days and CCl4 was given ip (2.5 mL kg-1) on day 8. CCl4-induced the increase of serum activities of gamma-glutamyl transpeptidase, alanine aminotransferase and alkaline phosphatase, bilirubin and MDA concentrations but decreased the hepatic glycogen. Verbena just partially protected the increase of γGT. Colchicine partially protected all the biomarkers studied. No changes in sleeping time were observed in CCl4-treated rats. The LD50 was higher than 30 mg kg-1.",

keywords = "Hepatic injury biomarkers, Liver damage, Partially protection, Verbena",

author = "Liliana Favari-Perozzi and Raquel Nava-{\'A}lvarez and Mel{\'e}ndez-Camargo, {Ma Estela}",

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T1 - Probable efecto hepatoprotector de la verbena en la hepatitis inducida con tetracloruro de carbono en la rata

AU - Favari-Perozzi, Liliana

AU - Nava-Álvarez, Raquel

AU - Meléndez-Camargo, Ma Estela

PY - 2007/7

Y1 - 2007/7

N2 - Verbena Carolina known as verbena is used in the Mexican folk medicine for the biliary diseases. The purpose of this study was to evaluate the hepatoprotective effects of verbena on the acute intoxication of CCl4 in female Wistar rats. The animals were protected with verbena and colchicine (positive control) orally for seven days and CCl4 was given ip (2.5 mL kg-1) on day 8. CCl4-induced the increase of serum activities of gamma-glutamyl transpeptidase, alanine aminotransferase and alkaline phosphatase, bilirubin and MDA concentrations but decreased the hepatic glycogen. Verbena just partially protected the increase of γGT. Colchicine partially protected all the biomarkers studied. No changes in sleeping time were observed in CCl4-treated rats. The LD50 was higher than 30 mg kg-1.

AB - Verbena Carolina known as verbena is used in the Mexican folk medicine for the biliary diseases. The purpose of this study was to evaluate the hepatoprotective effects of verbena on the acute intoxication of CCl4 in female Wistar rats. The animals were protected with verbena and colchicine (positive control) orally for seven days and CCl4 was given ip (2.5 mL kg-1) on day 8. CCl4-induced the increase of serum activities of gamma-glutamyl transpeptidase, alanine aminotransferase and alkaline phosphatase, bilirubin and MDA concentrations but decreased the hepatic glycogen. Verbena just partially protected the increase of γGT. Colchicine partially protected all the biomarkers studied. No changes in sleeping time were observed in CCl4-treated rats. The LD50 was higher than 30 mg kg-1.

KW - Hepatic injury biomarkers

KW - Liver damage

KW - Partially protection

KW - Verbena

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M3 - Artículo

SN - 1027-3956

VL - 38

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JO - Revista Mexicana de Ciencias Farmaceuticas

JF - Revista Mexicana de Ciencias Farmaceuticas

IS - 3

ER -

Probable efecto hepatoprotector de la verbena en la hepatitis inducida con tetracloruro de carbono en la rata

Abstract

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