MicroRNAs driving invasion and metastasis in ovarian cancer: Opportunities for translational medicine (Review)

Carlos Palma Flores, Raul Garcia-Vázquez, Dolores Gallardo Rincón, Erika Ruiz-Garcia, Horacio Astudillo De La Vega, Laurence A. Marchat, Yarely M. Salinas Vera, César López-Camarillo

Research output: Contribution to journalScientific review

17 Citations (Scopus)

Abstract

Epithelial ovarian cancer is the fifth most frequent cause of cancer death in women. In spite of the advantages in early detection and treatment options, overall survival rates have improved only slightly in the last decades. Therefore, alternative therapeutic approaches need to overcome resistance and improve the patient survival and outcome. MicroRNAs are evolutionary conserved small non-coding RNAs that function as negative regulators of gene expression by inhibiting translation or inducing degradation of messenger RNAs. In cancer, microRNAs are aberrantly expressed thus representing potential prognostic biomarkers and novel therapeutic targets. The knowledge of novel and unexpected functions of microRNAs is rapidly evolving and the advance in the elucidation of potential clinical applications deserves attention. Recently, a specific set of microRNAs dubbed as metastamiRs have been shown to initiate invasion and metastasis in diverse types of cancer. We reviewed the current status of microRNAs in development and progression of ovarian cancer with a special emphasis on tumor cells invasion and metastasis. Also, we show an update of microRNA functions in oncogenic pathways and discuss the current scenario for potential applications in clinical and translational research in ovarian cancer.
Original languageAmerican English
Pages (from-to)1461-1476
Number of pages16
JournalInternational Journal of Oncology
DOIs
StatePublished - 1 May 2017

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Translational Medical Research
MicroRNAs
Ovarian Neoplasms
Neoplasm Metastasis
Neoplasms
Small Untranslated RNA
Regulator Genes
Cause of Death
Therapeutics
Survival Rate
Biomarkers
Gene Expression
Messenger RNA
Survival

Cite this

Flores, C. P., Garcia-Vázquez, R., Rincón, D. G., Ruiz-Garcia, E., De La Vega, H. A., Marchat, L. A., ... López-Camarillo, C. (2017). MicroRNAs driving invasion and metastasis in ovarian cancer: Opportunities for translational medicine (Review). International Journal of Oncology, 1461-1476. https://doi.org/10.3892/ijo.2017.3948
Flores, Carlos Palma ; Garcia-Vázquez, Raul ; Rincón, Dolores Gallardo ; Ruiz-Garcia, Erika ; De La Vega, Horacio Astudillo ; Marchat, Laurence A. ; Salinas Vera, Yarely M. ; López-Camarillo, César. / MicroRNAs driving invasion and metastasis in ovarian cancer: Opportunities for translational medicine (Review). In: International Journal of Oncology. 2017 ; pp. 1461-1476.
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abstract = "Epithelial ovarian cancer is the fifth most frequent cause of cancer death in women. In spite of the advantages in early detection and treatment options, overall survival rates have improved only slightly in the last decades. Therefore, alternative therapeutic approaches need to overcome resistance and improve the patient survival and outcome. MicroRNAs are evolutionary conserved small non-coding RNAs that function as negative regulators of gene expression by inhibiting translation or inducing degradation of messenger RNAs. In cancer, microRNAs are aberrantly expressed thus representing potential prognostic biomarkers and novel therapeutic targets. The knowledge of novel and unexpected functions of microRNAs is rapidly evolving and the advance in the elucidation of potential clinical applications deserves attention. Recently, a specific set of microRNAs dubbed as metastamiRs have been shown to initiate invasion and metastasis in diverse types of cancer. We reviewed the current status of microRNAs in development and progression of ovarian cancer with a special emphasis on tumor cells invasion and metastasis. Also, we show an update of microRNA functions in oncogenic pathways and discuss the current scenario for potential applications in clinical and translational research in ovarian cancer.",
author = "Flores, {Carlos Palma} and Raul Garcia-V{\'a}zquez and Rinc{\'o}n, {Dolores Gallardo} and Erika Ruiz-Garcia and {De La Vega}, {Horacio Astudillo} and Marchat, {Laurence A.} and {Salinas Vera}, {Yarely M.} and C{\'e}sar L{\'o}pez-Camarillo",
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Flores, CP, Garcia-Vázquez, R, Rincón, DG, Ruiz-Garcia, E, De La Vega, HA, Marchat, LA, Salinas Vera, YM & López-Camarillo, C 2017, 'MicroRNAs driving invasion and metastasis in ovarian cancer: Opportunities for translational medicine (Review)', International Journal of Oncology, pp. 1461-1476. https://doi.org/10.3892/ijo.2017.3948

MicroRNAs driving invasion and metastasis in ovarian cancer: Opportunities for translational medicine (Review). / Flores, Carlos Palma; Garcia-Vázquez, Raul; Rincón, Dolores Gallardo; Ruiz-Garcia, Erika; De La Vega, Horacio Astudillo; Marchat, Laurence A.; Salinas Vera, Yarely M.; López-Camarillo, César.

In: International Journal of Oncology, 01.05.2017, p. 1461-1476.

Research output: Contribution to journalScientific review

TY - JOUR

T1 - MicroRNAs driving invasion and metastasis in ovarian cancer: Opportunities for translational medicine (Review)

AU - Flores, Carlos Palma

AU - Garcia-Vázquez, Raul

AU - Rincón, Dolores Gallardo

AU - Ruiz-Garcia, Erika

AU - De La Vega, Horacio Astudillo

AU - Marchat, Laurence A.

AU - Salinas Vera, Yarely M.

AU - López-Camarillo, César

PY - 2017/5/1

Y1 - 2017/5/1

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AB - Epithelial ovarian cancer is the fifth most frequent cause of cancer death in women. In spite of the advantages in early detection and treatment options, overall survival rates have improved only slightly in the last decades. Therefore, alternative therapeutic approaches need to overcome resistance and improve the patient survival and outcome. MicroRNAs are evolutionary conserved small non-coding RNAs that function as negative regulators of gene expression by inhibiting translation or inducing degradation of messenger RNAs. In cancer, microRNAs are aberrantly expressed thus representing potential prognostic biomarkers and novel therapeutic targets. The knowledge of novel and unexpected functions of microRNAs is rapidly evolving and the advance in the elucidation of potential clinical applications deserves attention. Recently, a specific set of microRNAs dubbed as metastamiRs have been shown to initiate invasion and metastasis in diverse types of cancer. We reviewed the current status of microRNAs in development and progression of ovarian cancer with a special emphasis on tumor cells invasion and metastasis. Also, we show an update of microRNA functions in oncogenic pathways and discuss the current scenario for potential applications in clinical and translational research in ovarian cancer.

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DO - 10.3892/ijo.2017.3948

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JO - International Journal of Oncology

JF - International Journal of Oncology

SN - 1019-6439

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