TY - JOUR
T1 - MicroRNAs driving invasion and metastasis in ovarian cancer
T2 - Opportunities for translational medicine (Review)
AU - Flores, Carlos Palma
AU - Garcia-Vázquez, Raul
AU - Rincón, Dolores Gallardo
AU - Ruiz-Garcia, Erika
AU - De La Vega, Horacio Astudillo
AU - Marchat, Laurence A.
AU - Salinas Vera, Yarely M.
AU - López-Camarillo, César
PY - 2017/5
Y1 - 2017/5
N2 - Epithelial ovarian cancer is the fifth most frequent cause of cancer death in women. In spite of the advantages in early detection and treatment options, overall survival rates have improved only slightly in the last decades. Therefore, alternative therapeutic approaches need to overcome resistance and improve the patient survival and outcome. MicroRNAs are evolutionary conserved small non-coding RNAs that function as negative regulators of gene expression by inhibiting translation or inducing degradation of messenger RNAs. In cancer, microRNAs are aberrantly expressed thus representing potential prognostic biomarkers and novel therapeutic targets. The knowledge of novel and unexpected functions of microRNAs is rapidly evolving and the advance in the elucidation of potential clinical applications deserves attention. Recently, a specific set of microRNAs dubbed as metastamiRs have been shown to initiate invasion and metastasis in diverse types of cancer. We reviewed the current status of microRNAs in development and progression of ovarian cancer with a special emphasis on tumor cells invasion and metastasis. Also, we show an update of microRNA functions in oncogenic pathways and discuss the current scenario for potential applications in clinical and translational research in ovarian cancer.
AB - Epithelial ovarian cancer is the fifth most frequent cause of cancer death in women. In spite of the advantages in early detection and treatment options, overall survival rates have improved only slightly in the last decades. Therefore, alternative therapeutic approaches need to overcome resistance and improve the patient survival and outcome. MicroRNAs are evolutionary conserved small non-coding RNAs that function as negative regulators of gene expression by inhibiting translation or inducing degradation of messenger RNAs. In cancer, microRNAs are aberrantly expressed thus representing potential prognostic biomarkers and novel therapeutic targets. The knowledge of novel and unexpected functions of microRNAs is rapidly evolving and the advance in the elucidation of potential clinical applications deserves attention. Recently, a specific set of microRNAs dubbed as metastamiRs have been shown to initiate invasion and metastasis in diverse types of cancer. We reviewed the current status of microRNAs in development and progression of ovarian cancer with a special emphasis on tumor cells invasion and metastasis. Also, we show an update of microRNA functions in oncogenic pathways and discuss the current scenario for potential applications in clinical and translational research in ovarian cancer.
KW - Epithelial-mesenchymal transition
KW - Invasion
KW - Metastasis
KW - MicroRNAs
KW - Ovarian cancer
KW - Translational medicine
UR - http://www.scopus.com/inward/record.url?scp=85018514268&partnerID=8YFLogxK
U2 - 10.3892/ijo.2017.3948
DO - 10.3892/ijo.2017.3948
M3 - Artículo de revisión
C2 - 28393213
SN - 1019-6439
VL - 50
SP - 1461
EP - 1476
JO - International Journal of Oncology
JF - International Journal of Oncology
IS - 5
ER -