TY - JOUR
T1 - Lectins as virulence factors in Entamoeba histolytica and free-living amoebae
AU - Guzmán-Téllez, Paula
AU - Martínez-Castillo, Moisés
AU - Flores-Huerta, Nadia
AU - Rosales-Morgan, Gabriela
AU - Pacheco-Yépez, Judith
AU - La Garza, Mireya De
AU - Serrano-Luna, Jesús
AU - Shibayama, Mineko
N1 - Publisher Copyright:
© 2020 Future Medicine Ltd.. All rights reserved.
PY - 2020/7
Y1 - 2020/7
N2 - Currently, there is growing interest in the identification and purification of microbial lectins due to their involvement in the pathogenicity mechanisms of pathogens, such as Entamoeba histolytica and free-living amoebae. The Gal/GalNAc lectin from E. histolytica participates in adhesion, cytotoxicity and regulation of immune responses. Furthermore, mannose- and galactose-binding protein have been described in Acanthamoeba castellanii and Balamuthia mandrillaris, respectively and they also contribute to host damage. Finally, in Naegleria fowleri, molecules containing mannose and fucose are implicated in adhesion and cytotoxicity. Considering their relevance in the pathogenesis of the diseases caused by these protozoa, lectins appear to be promising targets in the diagnosis, vaccination and treatment of these infections.
AB - Currently, there is growing interest in the identification and purification of microbial lectins due to their involvement in the pathogenicity mechanisms of pathogens, such as Entamoeba histolytica and free-living amoebae. The Gal/GalNAc lectin from E. histolytica participates in adhesion, cytotoxicity and regulation of immune responses. Furthermore, mannose- and galactose-binding protein have been described in Acanthamoeba castellanii and Balamuthia mandrillaris, respectively and they also contribute to host damage. Finally, in Naegleria fowleri, molecules containing mannose and fucose are implicated in adhesion and cytotoxicity. Considering their relevance in the pathogenesis of the diseases caused by these protozoa, lectins appear to be promising targets in the diagnosis, vaccination and treatment of these infections.
KW - Entamoeba histolytica
KW - carbohydrate-binding proteins
KW - free-living amoebae
KW - lectins
KW - pathogenicity mechanisms
UR - http://www.scopus.com/inward/record.url?scp=85090079244&partnerID=8YFLogxK
U2 - 10.2217/fmb-2019-0275
DO - 10.2217/fmb-2019-0275
M3 - Artículo de revisión
C2 - 32716210
AN - SCOPUS:85090079244
SN - 1746-0913
VL - 15
SP - 919
EP - 936
JO - Future Microbiology
JF - Future Microbiology
IS - 10
ER -