Intravascular Endothelial Surface Structures (IESS) mediate the cardiac effects of Coronary Flow (CF)

R. Rubio; G. Ceballos

Intravascular Endothelial Surface Structures (IESS) mediate the cardiac effects of Coronary Flow (CF)

Escuela Superior de Medicina (ESM)

Research output: Contribution to journal › Article › peer-review

Abstract

CF stimulatory effects (CF+) on A-V transmission (AV) and contraction (CT) possibly result via deforming forces acting on (IESS). IESS are glycosylated proteins with a high affinity for lectins (Ls); some IESS have been isolated and their antibodies (ab) are available. We reasoned that if various Ls or ab were intracoronarily infused in isolated perfused guinea pig hearts one would expect to produce specific modulation of CF+ on AV and CT. Different Ls (8) and ab (9) were tested. 6 of the 8 Ls inhibited the CF+-AV and none affected on CF+-CT. 3 of the 9 ab were effective. CF+-AV was selectively inhibited Syalyl L_b and integrin œ_vβ₅ ab, while the CF+-CT was solely potentiated by VCAM ab. Our results indicate that specific IESS may translate CF+ into modulation of specific functions. (Graph Presented).

Original language	English
Pages (from-to)	A671
Journal	FASEB Journal
Volume	12
Issue number	5
State	Published - 20 Mar 1998

Cite this

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title = "Intravascular Endothelial Surface Structures (IESS) mediate the cardiac effects of Coronary Flow (CF)",

abstract = "CF stimulatory effects (CF+) on A-V transmission (AV) and contraction (CT) possibly result via deforming forces acting on (IESS). IESS are glycosylated proteins with a high affinity for lectins (Ls); some IESS have been isolated and their antibodies (ab) are available. We reasoned that if various Ls or ab were intracoronarily infused in isolated perfused guinea pig hearts one would expect to produce specific modulation of CF+ on AV and CT. Different Ls (8) and ab (9) were tested. 6 of the 8 Ls inhibited the CF+-AV and none affected on CF+-CT. 3 of the 9 ab were effective. CF+-AV was selectively inhibited Syalyl Lb and integrin {\oe}vβ5 ab, while the CF+-CT was solely potentiated by VCAM ab. Our results indicate that specific IESS may translate CF+ into modulation of specific functions. (Graph Presented).",

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AU - Rubio, R.

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N2 - CF stimulatory effects (CF+) on A-V transmission (AV) and contraction (CT) possibly result via deforming forces acting on (IESS). IESS are glycosylated proteins with a high affinity for lectins (Ls); some IESS have been isolated and their antibodies (ab) are available. We reasoned that if various Ls or ab were intracoronarily infused in isolated perfused guinea pig hearts one would expect to produce specific modulation of CF+ on AV and CT. Different Ls (8) and ab (9) were tested. 6 of the 8 Ls inhibited the CF+-AV and none affected on CF+-CT. 3 of the 9 ab were effective. CF+-AV was selectively inhibited Syalyl Lb and integrin œvβ5 ab, while the CF+-CT was solely potentiated by VCAM ab. Our results indicate that specific IESS may translate CF+ into modulation of specific functions. (Graph Presented).

AB - CF stimulatory effects (CF+) on A-V transmission (AV) and contraction (CT) possibly result via deforming forces acting on (IESS). IESS are glycosylated proteins with a high affinity for lectins (Ls); some IESS have been isolated and their antibodies (ab) are available. We reasoned that if various Ls or ab were intracoronarily infused in isolated perfused guinea pig hearts one would expect to produce specific modulation of CF+ on AV and CT. Different Ls (8) and ab (9) were tested. 6 of the 8 Ls inhibited the CF+-AV and none affected on CF+-CT. 3 of the 9 ab were effective. CF+-AV was selectively inhibited Syalyl Lb and integrin œvβ5 ab, while the CF+-CT was solely potentiated by VCAM ab. Our results indicate that specific IESS may translate CF+ into modulation of specific functions. (Graph Presented).

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Intravascular Endothelial Surface Structures (IESS) mediate the cardiac effects of Coronary Flow (CF)

Abstract

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