Inflammatory response in human alveolar epithelial cells after TiO2 NPs or ZnO NPs exposure: Inhibition of surfactant protein A expression as an indicator for loss of lung function

A. Jiménez-Chávez; A. Solorio-Rodríguez; V. Escamilla-Rivera; D. Leseman; R. Morales-Rubio; M. Uribe-Ramírez; L. Campos-Villegas; I. E. Medina-Ramírez; L. Arreola-Mendoza; F. R. Cassee; A. De Vizcaya-Ruiz

doi:10.1016/j.etap.2021.103654

Inflammatory response in human alveolar epithelial cells after TiO₂ NPs or ZnO NPs exposure: Inhibition of surfactant protein A expression as an indicator for loss of lung function

A. Jiménez-Chávez, A. Solorio-Rodríguez, V. Escamilla-Rivera, D. Leseman, R. Morales-Rubio, M. Uribe-Ramírez, L. Campos-Villegas, I. E. Medina-Ramírez, L. Arreola-Mendoza, F. R. Cassee, A. De Vizcaya-Ruiz

Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y Desarrollo (CIIEMAD)

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The increasing use of metal oxide nanoparticles (MONPs) as TiO₂ NPs or ZnO NPs has led to environmental release and human exposure. The respiratory system, effects on lamellar bodies and surfactant protein A (SP-A) of pneumocytes, can be importantly affected. Exposure of human alveolar epithelial cells (A549) induced differential responses; a higher persistence of TiO₂ in cell surface and uptake (measured by Atomic Force Microscopy) and sustained inflammatory response (by means of TNF-α, IL-10, and IL-6 release) and ROS generation were observed, whereas ZnO showed a modest response and low numbers in cell surface. A reduction in SP-A levels at 24 h of exposure to TiO₂ NPs (concentration-dependent) or ZnO NPs (the higher concentration) was also observed, reversed by blocking the inflammatory response (by the inhibition of IL-6). Loss of SP-A represents a relevant target of MONPs-induced inflammatory response that could contribute to cellular damage and loss of lung function.

Original language	English
Article number	103654
Journal	Environmental Toxicology and Pharmacology
Volume	86
DOIs	https://doi.org/10.1016/j.etap.2021.103654
State	Published - Aug 2021

Keywords

Interleukin 6
MONPs biopersistence
Surfactant protein A
TiO NPs
ZnO NPs

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10.1016/j.etap.2021.103654

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Jiménez-Chávez, A., Solorio-Rodríguez, A., Escamilla-Rivera, V., Leseman, D., Morales-Rubio, R., Uribe-Ramírez, M., Campos-Villegas, L., Medina-Ramírez, I. E., Arreola-Mendoza, L., Cassee, F. R., & De Vizcaya-Ruiz, A. (2021). Inflammatory response in human alveolar epithelial cells after TiO₂ NPs or ZnO NPs exposure: Inhibition of surfactant protein A expression as an indicator for loss of lung function. Environmental Toxicology and Pharmacology, 86, Article 103654. https://doi.org/10.1016/j.etap.2021.103654

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title = "Inflammatory response in human alveolar epithelial cells after TiO2 NPs or ZnO NPs exposure: Inhibition of surfactant protein A expression as an indicator for loss of lung function",

abstract = "The increasing use of metal oxide nanoparticles (MONPs) as TiO2 NPs or ZnO NPs has led to environmental release and human exposure. The respiratory system, effects on lamellar bodies and surfactant protein A (SP-A) of pneumocytes, can be importantly affected. Exposure of human alveolar epithelial cells (A549) induced differential responses; a higher persistence of TiO2 in cell surface and uptake (measured by Atomic Force Microscopy) and sustained inflammatory response (by means of TNF-α, IL-10, and IL-6 release) and ROS generation were observed, whereas ZnO showed a modest response and low numbers in cell surface. A reduction in SP-A levels at 24 h of exposure to TiO2 NPs (concentration-dependent) or ZnO NPs (the higher concentration) was also observed, reversed by blocking the inflammatory response (by the inhibition of IL-6). Loss of SP-A represents a relevant target of MONPs-induced inflammatory response that could contribute to cellular damage and loss of lung function.",

keywords = "Interleukin 6, MONPs biopersistence, Surfactant protein A, TiO NPs, ZnO NPs",

author = "A. Jim{\'e}nez-Ch{\'a}vez and A. Solorio-Rodr{\'i}guez and V. Escamilla-Rivera and D. Leseman and R. Morales-Rubio and M. Uribe-Ram{\'i}rez and L. Campos-Villegas and Medina-Ram{\'i}rez, {I. E.} and L. Arreola-Mendoza and Cassee, {F. R.} and {De Vizcaya-Ruiz}, A.",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = aug,

doi = "10.1016/j.etap.2021.103654",

language = "Ingl{\'e}s",

volume = "86",

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Jiménez-Chávez, A, Solorio-Rodríguez, A, Escamilla-Rivera, V, Leseman, D, Morales-Rubio, R, Uribe-Ramírez, M, Campos-Villegas, L, Medina-Ramírez, IE, Arreola-Mendoza, L, Cassee, FR & De Vizcaya-Ruiz, A 2021, 'Inflammatory response in human alveolar epithelial cells after TiO₂ NPs or ZnO NPs exposure: Inhibition of surfactant protein A expression as an indicator for loss of lung function', Environmental Toxicology and Pharmacology, vol. 86, 103654. https://doi.org/10.1016/j.etap.2021.103654

Inflammatory response in human alveolar epithelial cells after TiO₂ NPs or ZnO NPs exposure: Inhibition of surfactant protein A expression as an indicator for loss of lung function. / Jiménez-Chávez, A.; Solorio-Rodríguez, A.; Escamilla-Rivera, V. et al.
In: Environmental Toxicology and Pharmacology, Vol. 86, 103654, 08.2021.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Inflammatory response in human alveolar epithelial cells after TiO2 NPs or ZnO NPs exposure

T2 - Inhibition of surfactant protein A expression as an indicator for loss of lung function

AU - Jiménez-Chávez, A.

AU - Solorio-Rodríguez, A.

AU - Escamilla-Rivera, V.

AU - Leseman, D.

AU - Morales-Rubio, R.

AU - Uribe-Ramírez, M.

AU - Campos-Villegas, L.

AU - Medina-Ramírez, I. E.

AU - Arreola-Mendoza, L.

AU - Cassee, F. R.

AU - De Vizcaya-Ruiz, A.

PY - 2021/8

Y1 - 2021/8

N2 - The increasing use of metal oxide nanoparticles (MONPs) as TiO2 NPs or ZnO NPs has led to environmental release and human exposure. The respiratory system, effects on lamellar bodies and surfactant protein A (SP-A) of pneumocytes, can be importantly affected. Exposure of human alveolar epithelial cells (A549) induced differential responses; a higher persistence of TiO2 in cell surface and uptake (measured by Atomic Force Microscopy) and sustained inflammatory response (by means of TNF-α, IL-10, and IL-6 release) and ROS generation were observed, whereas ZnO showed a modest response and low numbers in cell surface. A reduction in SP-A levels at 24 h of exposure to TiO2 NPs (concentration-dependent) or ZnO NPs (the higher concentration) was also observed, reversed by blocking the inflammatory response (by the inhibition of IL-6). Loss of SP-A represents a relevant target of MONPs-induced inflammatory response that could contribute to cellular damage and loss of lung function.

AB - The increasing use of metal oxide nanoparticles (MONPs) as TiO2 NPs or ZnO NPs has led to environmental release and human exposure. The respiratory system, effects on lamellar bodies and surfactant protein A (SP-A) of pneumocytes, can be importantly affected. Exposure of human alveolar epithelial cells (A549) induced differential responses; a higher persistence of TiO2 in cell surface and uptake (measured by Atomic Force Microscopy) and sustained inflammatory response (by means of TNF-α, IL-10, and IL-6 release) and ROS generation were observed, whereas ZnO showed a modest response and low numbers in cell surface. A reduction in SP-A levels at 24 h of exposure to TiO2 NPs (concentration-dependent) or ZnO NPs (the higher concentration) was also observed, reversed by blocking the inflammatory response (by the inhibition of IL-6). Loss of SP-A represents a relevant target of MONPs-induced inflammatory response that could contribute to cellular damage and loss of lung function.

KW - Interleukin 6

KW - MONPs biopersistence

KW - Surfactant protein A

KW - TiO NPs

KW - ZnO NPs

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U2 - 10.1016/j.etap.2021.103654

DO - 10.1016/j.etap.2021.103654

M3 - Artículo

C2 - 33823299

AN - SCOPUS:85103792050

SN - 1382-6689

VL - 86

JO - Environmental Toxicology and Pharmacology

JF - Environmental Toxicology and Pharmacology

M1 - 103654

ER -

Jiménez-Chávez A, Solorio-Rodríguez A, Escamilla-Rivera V, Leseman D, Morales-Rubio R, Uribe-Ramírez M et al. Inflammatory response in human alveolar epithelial cells after TiO₂ NPs or ZnO NPs exposure: Inhibition of surfactant protein A expression as an indicator for loss of lung function. Environmental Toxicology and Pharmacology. 2021 Aug;86:103654. doi: 10.1016/j.etap.2021.103654

Inflammatory response in human alveolar epithelial cells after TiO₂ NPs or ZnO NPs exposure: Inhibition of surfactant protein A expression as an indicator for loss of lung function

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Keywords

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