Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads

Dalia Charles-Navarro; Virgilio Bocanegra-García; Isidro Palos; Gildardo Rivera; Patricia Esquivel-Ferriño; Sandra Gracia-Vásquez; Rolffy Ortiz-Andrade; Jesús Quiroz-Velásquez; José Luis Hernández-Mendoza

doi:10.1590/S0100-40422010000700002

Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads

Dalia Charles-Navarro, Virgilio Bocanegra-García, Isidro Palos, Gildardo Rivera, Patricia Esquivel-Ferriño, Sandra Gracia-Vásquez, Rolffy Ortiz-Andrade, Jesús Quiroz-Velásquez, José Luis Hernández-Mendoza

Centro de Biotecnología Genómica (CBG)

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil ^® and Glibetab^®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 μm. For the in vitro dissolution test Daonil^® at 45 min showed a Q > 70%, whereas Glibetab^® and glibenclamide calciumalginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties. Keywords: glibenclamide; calcium-alginate beads; dissolution.

Original language	English
Pages (from-to)	1435-1439
Number of pages	5
Journal	Quimica Nova
Volume	33
Issue number	7
DOIs	https://doi.org/10.1590/S0100-40422010000700002
State	Published - 2010

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title = "Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads",

abstract = "The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil {\textregistered} and Glibetab{\textregistered}). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 μm. For the in vitro dissolution test Daonil{\textregistered} at 45 min showed a Q > 70%, whereas Glibetab{\textregistered} and glibenclamide calciumalginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties. Keywords: glibenclamide; calcium-alginate beads; dissolution.",

author = "Dalia Charles-Navarro and Virgilio Bocanegra-Garc{\'i}a and Isidro Palos and Gildardo Rivera and Patricia Esquivel-Ferri{\~n}o and Sandra Gracia-V{\'a}squez and Rolffy Ortiz-Andrade and Jes{\'u}s Quiroz-Vel{\'a}squez and Hern{\'a}ndez-Mendoza, {Jos{\'e} Luis}",

year = "2010",

doi = "10.1590/S0100-40422010000700002",

language = "Ingl{\'e}s",

volume = "33",

pages = "1435--1439",

journal = "Quimica Nova",

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TY - JOUR

T1 - Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads

AU - Charles-Navarro, Dalia

AU - Bocanegra-García, Virgilio

AU - Palos, Isidro

AU - Rivera, Gildardo

AU - Esquivel-Ferriño, Patricia

AU - Gracia-Vásquez, Sandra

AU - Ortiz-Andrade, Rolffy

AU - Quiroz-Velásquez, Jesús

AU - Hernández-Mendoza, José Luis

PY - 2010

Y1 - 2010

N2 - The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil ® and Glibetab®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 μm. For the in vitro dissolution test Daonil® at 45 min showed a Q > 70%, whereas Glibetab® and glibenclamide calciumalginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties. Keywords: glibenclamide; calcium-alginate beads; dissolution.

AB - The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil ® and Glibetab®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 μm. For the in vitro dissolution test Daonil® at 45 min showed a Q > 70%, whereas Glibetab® and glibenclamide calciumalginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties. Keywords: glibenclamide; calcium-alginate beads; dissolution.

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U2 - 10.1590/S0100-40422010000700002

DO - 10.1590/S0100-40422010000700002

M3 - Artículo

SN - 0100-4042

VL - 33

SP - 1435

EP - 1439

JO - Quimica Nova

JF - Quimica Nova

IS - 7

ER -

Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads

Abstract

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