Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads

Dalia Charles-Navarro, Virgilio Bocanegra-García, Isidro Palos, Gildardo Rivera, Patricia Esquivel-Ferriño, Sandra Gracia-Vásquez, Rolffy Ortiz-Andrade, Jesús Quiroz-Velásquez, José Luis Hernández-Mendoza

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Abstract

The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil®and Glibetab®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 μm. For the in vitro dissolution test Daonil®at 45 min showed a Q > 70%, whereas Glibetab®and glibenclamide calciumalginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties. Keywords: glibenclamide; calcium-alginate beads; dissolution.
Original languageAmerican English
Pages (from-to)1435-1439
Number of pages5
JournalQuimica Nova
DOIs
StatePublished - 1 Jan 2010

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