TY - JOUR
T1 - Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads
AU - Charles-Navarro, Dalia
AU - Bocanegra-García, Virgilio
AU - Palos, Isidro
AU - Rivera, Gildardo
AU - Esquivel-Ferriño, Patricia
AU - Gracia-Vásquez, Sandra
AU - Ortiz-Andrade, Rolffy
AU - Quiroz-Velásquez, Jesús
AU - Hernández-Mendoza, José Luis
PY - 2010
Y1 - 2010
N2 - The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil ® and Glibetab®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 μm. For the in vitro dissolution test Daonil® at 45 min showed a Q > 70%, whereas Glibetab® and glibenclamide calciumalginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties. Keywords: glibenclamide; calcium-alginate beads; dissolution.
AB - The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil ® and Glibetab®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 μm. For the in vitro dissolution test Daonil® at 45 min showed a Q > 70%, whereas Glibetab® and glibenclamide calciumalginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties. Keywords: glibenclamide; calcium-alginate beads; dissolution.
UR - http://www.scopus.com/inward/record.url?scp=78449283503&partnerID=8YFLogxK
U2 - 10.1590/S0100-40422010000700002
DO - 10.1590/S0100-40422010000700002
M3 - Artículo
SN - 0100-4042
VL - 33
SP - 1435
EP - 1439
JO - Quimica Nova
JF - Quimica Nova
IS - 7
ER -