Effect of silymarin supplementation in lung and liver histological modifications during exercise training in a rodent model

Nancy Vargas-Mendoza; Marcelo Angeles-Valencia; Ángel Morales-González; Mauricio Morales-Martínez; Eduardo Madrigal-Bujaidar; Isela Álvarez-González; Tomás Fregoso-Aguilar; Luis Delgado-Olivares; Eduardo Osiris Madrigal-Santillán; José A. Morales-González

doi:10.3390/jfmk6030072

Effect of silymarin supplementation in lung and liver histological modifications during exercise training in a rodent model

Nancy Vargas-Mendoza, Marcelo Angeles-Valencia, Ángel Morales-González, Mauricio Morales-Martínez, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Tomás Fregoso-Aguilar, Luis Delgado-Olivares, Eduardo Osiris Madrigal-Santillán, José A. Morales-González

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2 Scopus citations

Abstract

Background: Exercise training induces adaptive physiological and morphological modifications in the entire organism; however, excessive loads of training may increase damage in tissues. The purpose of this study was to evaluate the effect of silymarin in lung and liver histological changes in rats subjected to exercise training (ET). Methods: Male Wistar rats were subjected to an 8-week ET treadmill program 5 days per week, 60 min/session, and were previously administered 100 mg ascorbic acid or 100 mg of silymarin. Results: Silymarin increased alveolar and bronchial muscle size, improve vascularization, and reduced tissue inflammation. In liver, silymarin promoted the reduction of lipid content. Conclusion: Silymarin supplementation may improve inflammation in pulmonary tissue after 8 weeks of the ET treadmill program, improve cell recovery, and reduce intrahepatic lipid content.

Original language	English
Article number	72
Journal	Journal of Functional Morphology and Kinesiology
Volume	6
Issue number	3
DOIs	https://doi.org/10.3390/jfmk6030072
State	Published - Sep 2021

Keywords

Exercise training
Histological changes
Inflammation
Liver
Lung
Silymarin

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10.3390/jfmk6030072

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Vargas-Mendoza, N., Angeles-Valencia, M., Morales-González, Á., Morales-Martínez, M., Madrigal-Bujaidar, E., Álvarez-González, I., Fregoso-Aguilar, T., Delgado-Olivares, L., Madrigal-Santillán, E. O., & Morales-González, J. A. (2021). Effect of silymarin supplementation in lung and liver histological modifications during exercise training in a rodent model. Journal of Functional Morphology and Kinesiology, 6(3), Article 72. https://doi.org/10.3390/jfmk6030072

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title = "Effect of silymarin supplementation in lung and liver histological modifications during exercise training in a rodent model",

abstract = "Background: Exercise training induces adaptive physiological and morphological modifications in the entire organism; however, excessive loads of training may increase damage in tissues. The purpose of this study was to evaluate the effect of silymarin in lung and liver histological changes in rats subjected to exercise training (ET). Methods: Male Wistar rats were subjected to an 8-week ET treadmill program 5 days per week, 60 min/session, and were previously administered 100 mg ascorbic acid or 100 mg of silymarin. Results: Silymarin increased alveolar and bronchial muscle size, improve vascularization, and reduced tissue inflammation. In liver, silymarin promoted the reduction of lipid content. Conclusion: Silymarin supplementation may improve inflammation in pulmonary tissue after 8 weeks of the ET treadmill program, improve cell recovery, and reduce intrahepatic lipid content.",

keywords = "Exercise training, Histological changes, Inflammation, Liver, Lung, Silymarin",

author = "Nancy Vargas-Mendoza and Marcelo Angeles-Valencia and {\'A}ngel Morales-Gonz{\'a}lez and Mauricio Morales-Mart{\'i}nez and Eduardo Madrigal-Bujaidar and Isela {\'A}lvarez-Gonz{\'a}lez and Tom{\'a}s Fregoso-Aguilar and Luis Delgado-Olivares and Madrigal-Santill{\'a}n, {Eduardo Osiris} and Morales-Gonz{\'a}lez, {Jos{\'e} A.}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = sep,

doi = "10.3390/jfmk6030072",

language = "Ingl{\'e}s",

volume = "6",

journal = "Journal of Functional Morphology and Kinesiology",

issn = "2411-5142",

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Vargas-Mendoza, N, Angeles-Valencia, M, Morales-González, Á, Morales-Martínez, M, Madrigal-Bujaidar, E, Álvarez-González, I, Fregoso-Aguilar, T, Delgado-Olivares, L, Madrigal-Santillán, EO & Morales-González, JA 2021, 'Effect of silymarin supplementation in lung and liver histological modifications during exercise training in a rodent model', Journal of Functional Morphology and Kinesiology, vol. 6, no. 3, 72. https://doi.org/10.3390/jfmk6030072

TY - JOUR

T1 - Effect of silymarin supplementation in lung and liver histological modifications during exercise training in a rodent model

AU - Vargas-Mendoza, Nancy

AU - Angeles-Valencia, Marcelo

AU - Morales-González, Ángel

AU - Morales-Martínez, Mauricio

AU - Madrigal-Bujaidar, Eduardo

AU - Álvarez-González, Isela

AU - Fregoso-Aguilar, Tomás

AU - Delgado-Olivares, Luis

AU - Madrigal-Santillán, Eduardo Osiris

AU - Morales-González, José A.

PY - 2021/9

Y1 - 2021/9

N2 - Background: Exercise training induces adaptive physiological and morphological modifications in the entire organism; however, excessive loads of training may increase damage in tissues. The purpose of this study was to evaluate the effect of silymarin in lung and liver histological changes in rats subjected to exercise training (ET). Methods: Male Wistar rats were subjected to an 8-week ET treadmill program 5 days per week, 60 min/session, and were previously administered 100 mg ascorbic acid or 100 mg of silymarin. Results: Silymarin increased alveolar and bronchial muscle size, improve vascularization, and reduced tissue inflammation. In liver, silymarin promoted the reduction of lipid content. Conclusion: Silymarin supplementation may improve inflammation in pulmonary tissue after 8 weeks of the ET treadmill program, improve cell recovery, and reduce intrahepatic lipid content.

AB - Background: Exercise training induces adaptive physiological and morphological modifications in the entire organism; however, excessive loads of training may increase damage in tissues. The purpose of this study was to evaluate the effect of silymarin in lung and liver histological changes in rats subjected to exercise training (ET). Methods: Male Wistar rats were subjected to an 8-week ET treadmill program 5 days per week, 60 min/session, and were previously administered 100 mg ascorbic acid or 100 mg of silymarin. Results: Silymarin increased alveolar and bronchial muscle size, improve vascularization, and reduced tissue inflammation. In liver, silymarin promoted the reduction of lipid content. Conclusion: Silymarin supplementation may improve inflammation in pulmonary tissue after 8 weeks of the ET treadmill program, improve cell recovery, and reduce intrahepatic lipid content.

KW - Exercise training

KW - Histological changes

KW - Inflammation

KW - Liver

KW - Lung

KW - Silymarin

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U2 - 10.3390/jfmk6030072

DO - 10.3390/jfmk6030072

M3 - Artículo

C2 - 34564191

AN - SCOPUS:85114667901

SN - 2411-5142

VL - 6

JO - Journal of Functional Morphology and Kinesiology

JF - Journal of Functional Morphology and Kinesiology

IS - 3

M1 - 72

ER -

Effect of silymarin supplementation in lung and liver histological modifications during exercise training in a rodent model

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