TY - JOUR
T1 - Effect of silymarin supplementation in lung and liver histological modifications during exercise training in a rodent model
AU - Vargas-Mendoza, Nancy
AU - Angeles-Valencia, Marcelo
AU - Morales-González, Ángel
AU - Morales-Martínez, Mauricio
AU - Madrigal-Bujaidar, Eduardo
AU - Álvarez-González, Isela
AU - Fregoso-Aguilar, Tomás
AU - Delgado-Olivares, Luis
AU - Madrigal-Santillán, Eduardo Osiris
AU - Morales-González, José A.
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/9
Y1 - 2021/9
N2 - Background: Exercise training induces adaptive physiological and morphological modifications in the entire organism; however, excessive loads of training may increase damage in tissues. The purpose of this study was to evaluate the effect of silymarin in lung and liver histological changes in rats subjected to exercise training (ET). Methods: Male Wistar rats were subjected to an 8-week ET treadmill program 5 days per week, 60 min/session, and were previously administered 100 mg ascorbic acid or 100 mg of silymarin. Results: Silymarin increased alveolar and bronchial muscle size, improve vascularization, and reduced tissue inflammation. In liver, silymarin promoted the reduction of lipid content. Conclusion: Silymarin supplementation may improve inflammation in pulmonary tissue after 8 weeks of the ET treadmill program, improve cell recovery, and reduce intrahepatic lipid content.
AB - Background: Exercise training induces adaptive physiological and morphological modifications in the entire organism; however, excessive loads of training may increase damage in tissues. The purpose of this study was to evaluate the effect of silymarin in lung and liver histological changes in rats subjected to exercise training (ET). Methods: Male Wistar rats were subjected to an 8-week ET treadmill program 5 days per week, 60 min/session, and were previously administered 100 mg ascorbic acid or 100 mg of silymarin. Results: Silymarin increased alveolar and bronchial muscle size, improve vascularization, and reduced tissue inflammation. In liver, silymarin promoted the reduction of lipid content. Conclusion: Silymarin supplementation may improve inflammation in pulmonary tissue after 8 weeks of the ET treadmill program, improve cell recovery, and reduce intrahepatic lipid content.
KW - Exercise training
KW - Histological changes
KW - Inflammation
KW - Liver
KW - Lung
KW - Silymarin
UR - http://www.scopus.com/inward/record.url?scp=85114667901&partnerID=8YFLogxK
U2 - 10.3390/jfmk6030072
DO - 10.3390/jfmk6030072
M3 - Artículo
C2 - 34564191
AN - SCOPUS:85114667901
SN - 2411-5142
VL - 6
JO - Journal of Functional Morphology and Kinesiology
JF - Journal of Functional Morphology and Kinesiology
IS - 3
M1 - 72
ER -