TY - JOUR
T1 - Effect of L-arginine oral supplementation on response to myocardial infarction in hypercholesterolemic and hypertensive rats
AU - Piñeiro, Verónica
AU - Ortiz-Moreno, Alicia
AU - Mora-Escobedo, Rosalva
AU - Hernández-Navarro, María Dolores
AU - Ceballos-Reyes, Guillermo
AU - Chamorro-Cevallos, Germán
N1 - Funding Information:
Acknowledgements Our gratitude to Alpha Program of the European Commission and to the Direction of Research (IPN-Mexico) for funding this study; to PhD Leticia Garduño Siciliano of the Preclinical Toxicology Laboratory at the National School of Biological Sciences (ENCB-IPN) and to the MS María Alejandra Guillén Orozco from the Pharmacology Department (The Superior School of Medicine-IPN).
PY - 2010/3
Y1 - 2010/3
N2 - The well known metabolic functions of L-arginine have been recently increased with the discovery of its role as the substrate for the synthesis of nitric oxide (NO), which has emerged as an endogenous signaling molecule with potential therapeutic implications for cardiovascular disease. Steady-state levels of NO are derived in part from dietary sources. It has been reported that supplementation of L-arginine reduces atherosclerosis in rabbits and reduces the arterial pressure in hypertensive rats. Therefore, we investigated the effect of L-arginine supplementation using a group of induced hypercholesterolemic rats and a group of spontaneously hypertensive rats; the infarcted area in cardiac tissue of both groups was measured during the response to myocardial infarction in the ischemia-reperfusion model. Hypercholesterolemic rats supplemented with 170 mg kg-1 of L-arginine showed a significant (P≤0.05) reduction in total cholesterol (25.2%) and LDL (27.8%). Spontaneously hypertensive rats supplemented with L-arginine presented a significant reduction (20.3%) in mean blood pressure (P ≤0.05). The index infarcted area / total heart area, in both: Hypercholesterolemic and hypertensive rats supplemented with L-arginine, showed a significant 36% and 29% of cardio protection (P ≤0.05) effect, respectively. Dietary supplementation with L-arginine may represent a potentially novel nutritional strategy for the treatment of cardiovascular disease.
AB - The well known metabolic functions of L-arginine have been recently increased with the discovery of its role as the substrate for the synthesis of nitric oxide (NO), which has emerged as an endogenous signaling molecule with potential therapeutic implications for cardiovascular disease. Steady-state levels of NO are derived in part from dietary sources. It has been reported that supplementation of L-arginine reduces atherosclerosis in rabbits and reduces the arterial pressure in hypertensive rats. Therefore, we investigated the effect of L-arginine supplementation using a group of induced hypercholesterolemic rats and a group of spontaneously hypertensive rats; the infarcted area in cardiac tissue of both groups was measured during the response to myocardial infarction in the ischemia-reperfusion model. Hypercholesterolemic rats supplemented with 170 mg kg-1 of L-arginine showed a significant (P≤0.05) reduction in total cholesterol (25.2%) and LDL (27.8%). Spontaneously hypertensive rats supplemented with L-arginine presented a significant reduction (20.3%) in mean blood pressure (P ≤0.05). The index infarcted area / total heart area, in both: Hypercholesterolemic and hypertensive rats supplemented with L-arginine, showed a significant 36% and 29% of cardio protection (P ≤0.05) effect, respectively. Dietary supplementation with L-arginine may represent a potentially novel nutritional strategy for the treatment of cardiovascular disease.
KW - Cholesterol
KW - Dyslipidemia
KW - Hypercholesterolemia
KW - Hypertension
KW - Ischemia-reperfusion
KW - L-arginine
UR - http://www.scopus.com/inward/record.url?scp=77949571197&partnerID=8YFLogxK
U2 - 10.1007/s11130-009-0143-y
DO - 10.1007/s11130-009-0143-y
M3 - Artículo
SN - 0921-9668
VL - 65
SP - 31
EP - 37
JO - Plant Foods for Human Nutrition
JF - Plant Foods for Human Nutrition
IS - 1
ER -