Diterpenoids from the freshwater green algae Rhizoclonium hieroglyphicum with antibacterial activity

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Abstract

Three new isopimarane diterpenes 7-hydroxy-19-methylmalonyloxy-isopimara- 8(14),15-diene (1), 7β-hydroxy-14-oxo-isopimara-8(9),15-dien-19oic acid (2), and 7β-hydroxy-14-oxo-19α-methylmalonyloxy-isopimara-9(11),15- diene (3) in addition to the known compounds isopimaric acid (4), 7oxo-13-epi-pimara-14,15-dien-18oic acid (5), 7oxo-13-epi-pimara-8,15-dien-18oic acid (6), and 6β-hydroxyisopimaric acid (7) were isolated from the hexane extract of Rhizoclonium hieroglyphicum. The structures of compounds 1-7 were established by 1D and 2D NMR techniques. The isolated diterpenoids were screened for antimicrobial activity against gram-positive and gram-negative bacteria and yeast strains. © 2011 Taylor & Francis.
Original languageAmerican English
Pages (from-to)934-941
Number of pages839
JournalJournal of Asian Natural Products Research
DOIs
StatePublished - 1 Oct 2011

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Chlorophyta
Diterpenes
Algae
Fresh Water
Acids
Hexanes
Gram-Negative Bacteria
Yeast
Bacteria
Yeasts
Nuclear magnetic resonance

Cite this

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title = "Diterpenoids from the freshwater green algae Rhizoclonium hieroglyphicum with antibacterial activity",
abstract = "Three new isopimarane diterpenes 7-hydroxy-19-methylmalonyloxy-isopimara- 8(14),15-diene (1), 7β-hydroxy-14-oxo-isopimara-8(9),15-dien-19oic acid (2), and 7β-hydroxy-14-oxo-19α-methylmalonyloxy-isopimara-9(11),15- diene (3) in addition to the known compounds isopimaric acid (4), 7oxo-13-epi-pimara-14,15-dien-18oic acid (5), 7oxo-13-epi-pimara-8,15-dien-18oic acid (6), and 6β-hydroxyisopimaric acid (7) were isolated from the hexane extract of Rhizoclonium hieroglyphicum. The structures of compounds 1-7 were established by 1D and 2D NMR techniques. The isolated diterpenoids were screened for antimicrobial activity against gram-positive and gram-negative bacteria and yeast strains. {\circledC} 2011 Taylor & Francis.",
author = "{Perez Gutierrez}, {Rosa Martha} and {Garcia Baez}, Efren",
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AU - Perez Gutierrez, Rosa Martha

AU - Garcia Baez, Efren

PY - 2011/10/1

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N2 - Three new isopimarane diterpenes 7-hydroxy-19-methylmalonyloxy-isopimara- 8(14),15-diene (1), 7β-hydroxy-14-oxo-isopimara-8(9),15-dien-19oic acid (2), and 7β-hydroxy-14-oxo-19α-methylmalonyloxy-isopimara-9(11),15- diene (3) in addition to the known compounds isopimaric acid (4), 7oxo-13-epi-pimara-14,15-dien-18oic acid (5), 7oxo-13-epi-pimara-8,15-dien-18oic acid (6), and 6β-hydroxyisopimaric acid (7) were isolated from the hexane extract of Rhizoclonium hieroglyphicum. The structures of compounds 1-7 were established by 1D and 2D NMR techniques. The isolated diterpenoids were screened for antimicrobial activity against gram-positive and gram-negative bacteria and yeast strains. © 2011 Taylor & Francis.

AB - Three new isopimarane diterpenes 7-hydroxy-19-methylmalonyloxy-isopimara- 8(14),15-diene (1), 7β-hydroxy-14-oxo-isopimara-8(9),15-dien-19oic acid (2), and 7β-hydroxy-14-oxo-19α-methylmalonyloxy-isopimara-9(11),15- diene (3) in addition to the known compounds isopimaric acid (4), 7oxo-13-epi-pimara-14,15-dien-18oic acid (5), 7oxo-13-epi-pimara-8,15-dien-18oic acid (6), and 6β-hydroxyisopimaric acid (7) were isolated from the hexane extract of Rhizoclonium hieroglyphicum. The structures of compounds 1-7 were established by 1D and 2D NMR techniques. The isolated diterpenoids were screened for antimicrobial activity against gram-positive and gram-negative bacteria and yeast strains. © 2011 Taylor & Francis.

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