TY - JOUR
T1 - Cardiac Conduction Model for Generating 12 Lead ECG Signals with Realistic Heart Rate Dynamics
AU - Quiroz-Juarez, Mario A.
AU - Jimenez-Ramirez, Omar
AU - Vazquez-Medina, Ruben
AU - Ryzhii, Elena
AU - Ryzhii, Maxim
AU - Aragon, Jose L.
N1 - Publisher Copyright:
© 2002-2011 IEEE.
PY - 2018/10
Y1 - 2018/10
N2 - We present an extended heterogeneous oscillator model of cardiac conduction system for generation of realistic 12 lead ECG waveforms. The model consists of main natural pacemakers represented by modified van der Pol equations, and atrial and ventricular muscles, in which the depolarization and repolarization processes are described by modified FitzHugh-Nagumo equations. We incorporate an artificial RR-tachogram with the specific statistics of a heart rate, the frequency-domain characteristics of heart rate variability produced by Mayer and respiratory sinus arrhythmia waves, normally distributed additive noise and a baseline wander that couple the respiratory frequency. The standard 12 lead ECG is calculated by means of a weighted linear combination of atria and ventricle signals and thus can be fitted to clinical ECG of real subject. The model is capable to simulate accurately realistic ECG characteristics including local pathological phenomena accounting for biophysical properties of the human heart. All these features provide significant advantages over existing nonlinear cardiac models. The proposed model constitutes a useful tool for medical education and for assessment and testing of ECG signal processing software and hardware systems.
AB - We present an extended heterogeneous oscillator model of cardiac conduction system for generation of realistic 12 lead ECG waveforms. The model consists of main natural pacemakers represented by modified van der Pol equations, and atrial and ventricular muscles, in which the depolarization and repolarization processes are described by modified FitzHugh-Nagumo equations. We incorporate an artificial RR-tachogram with the specific statistics of a heart rate, the frequency-domain characteristics of heart rate variability produced by Mayer and respiratory sinus arrhythmia waves, normally distributed additive noise and a baseline wander that couple the respiratory frequency. The standard 12 lead ECG is calculated by means of a weighted linear combination of atria and ventricle signals and thus can be fitted to clinical ECG of real subject. The model is capable to simulate accurately realistic ECG characteristics including local pathological phenomena accounting for biophysical properties of the human heart. All these features provide significant advantages over existing nonlinear cardiac models. The proposed model constitutes a useful tool for medical education and for assessment and testing of ECG signal processing software and hardware systems.
KW - 12 lead ECG
KW - Heart model
KW - cardiac conduction system
KW - differential equations
KW - heart rate variability
UR - http://www.scopus.com/inward/record.url?scp=85053361223&partnerID=8YFLogxK
U2 - 10.1109/TNB.2018.2870331
DO - 10.1109/TNB.2018.2870331
M3 - Artículo
C2 - 30235141
SN - 1536-1241
VL - 17
SP - 525
EP - 532
JO - IEEE Transactions on Nanobioscience
JF - IEEE Transactions on Nanobioscience
IS - 4
M1 - 8466837
ER -