Blood Glucose Regulation in Patients with Type 1 Diabetes Mellitus: A Robust MRAC Approach

Roberto Franco; Hector Rios; Alejandra Ferreira De Loza; Denis Efimov; Louis Cassany; David Gucik-Derigny; Jerome Cieslak; David Henry

doi:10.1109/CDC45484.2021.9683408

Blood Glucose Regulation in Patients with Type 1 Diabetes Mellitus: A Robust MRAC Approach

Roberto Franco, Hector Rios, Alejandra Ferreira De Loza, Denis Efimov, Louis Cassany, David Gucik-Derigny, Jerome Cieslak, David Henry

Centro de Investigación y Desarrollo de Tecnología Digital (CITEDI)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

This paper deals with the problem of robust blood glucose regulation in critically ill patients affected by type 1 diabetes mellitus. The blood glucose measurement and insulin infusion are intravenous. The proposed algorithm regulates blood glucose and keeps it in the normoglycemia range, i.e., 70-180 mg/dl. To this aim, a control law is proposed based on a Nonlinear Model Reference Adaptive Control approach. The algorithm is composed of nonlinear adaptive gains that ensure convergence to zero of the regulation error. The approach is validated in the UVA/Padova metabolic simulator for ten in silico adult patients with unannounced meals. The results perform well and have minimal risk of hyperglycemic and hypoglycemic events.

Original language	English
Title of host publication	60th IEEE Conference on Decision and Control, CDC 2021
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	661-666
Number of pages	6
ISBN (Electronic)	9781665436595
DOIs	https://doi.org/10.1109/CDC45484.2021.9683408
State	Published - 2021
Event	60th IEEE Conference on Decision and Control, CDC 2021 - Austin, United States Duration: 13 Dec 2021 → 17 Dec 2021

Publication series

Name	Proceedings of the IEEE Conference on Decision and Control
Volume	2021-December
ISSN (Print)	0743-1546
ISSN (Electronic)	2576-2370

Conference

Conference	60th IEEE Conference on Decision and Control, CDC 2021
Country/Territory	United States
City	Austin
Period	13/12/21 → 17/12/21

Keywords

Adaptive Control
Blood Glucose Regulation
Diabetes Mellitus Type 1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/CDC45484.2021.9683408

Cite this

Franco, R., Rios, H., De Loza, A. F., Efimov, D., Cassany, L., Gucik-Derigny, D., Cieslak, J., & Henry, D. (2021). Blood Glucose Regulation in Patients with Type 1 Diabetes Mellitus: A Robust MRAC Approach. In 60th IEEE Conference on Decision and Control, CDC 2021 (pp. 661-666). (Proceedings of the IEEE Conference on Decision and Control; Vol. 2021-December). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CDC45484.2021.9683408

@inproceedings{b6c44fe06d1b48cba3ba51af02cb7610,

title = "Blood Glucose Regulation in Patients with Type 1 Diabetes Mellitus: A Robust MRAC Approach",

abstract = "This paper deals with the problem of robust blood glucose regulation in critically ill patients affected by type 1 diabetes mellitus. The blood glucose measurement and insulin infusion are intravenous. The proposed algorithm regulates blood glucose and keeps it in the normoglycemia range, i.e., 70-180 mg/dl. To this aim, a control law is proposed based on a Nonlinear Model Reference Adaptive Control approach. The algorithm is composed of nonlinear adaptive gains that ensure convergence to zero of the regulation error. The approach is validated in the UVA/Padova metabolic simulator for ten in silico adult patients with unannounced meals. The results perform well and have minimal risk of hyperglycemic and hypoglycemic events.",

keywords = "Adaptive Control, Blood Glucose Regulation, Diabetes Mellitus Type 1",

author = "Roberto Franco and Hector Rios and {De Loza}, {Alejandra Ferreira} and Denis Efimov and Louis Cassany and David Gucik-Derigny and Jerome Cieslak and David Henry",

note = "Publisher Copyright: {\textcopyright} 2021 IEEE.; 60th IEEE Conference on Decision and Control, CDC 2021 ; Conference date: 13-12-2021 Through 17-12-2021",

year = "2021",

doi = "10.1109/CDC45484.2021.9683408",

language = "Ingl{\'e}s",

series = "Proceedings of the IEEE Conference on Decision and Control",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "661--666",

booktitle = "60th IEEE Conference on Decision and Control, CDC 2021",

address = "Estados Unidos",

}

Franco, R, Rios, H, De Loza, AF, Efimov, D, Cassany, L, Gucik-Derigny, D, Cieslak, J & Henry, D 2021, Blood Glucose Regulation in Patients with Type 1 Diabetes Mellitus: A Robust MRAC Approach. in 60th IEEE Conference on Decision and Control, CDC 2021. Proceedings of the IEEE Conference on Decision and Control, vol. 2021-December, Institute of Electrical and Electronics Engineers Inc., pp. 661-666, 60th IEEE Conference on Decision and Control, CDC 2021, Austin, United States, 13/12/21. https://doi.org/10.1109/CDC45484.2021.9683408

Blood Glucose Regulation in Patients with Type 1 Diabetes Mellitus: A Robust MRAC Approach. / Franco, Roberto; Rios, Hector; De Loza, Alejandra Ferreira et al.
60th IEEE Conference on Decision and Control, CDC 2021. Institute of Electrical and Electronics Engineers Inc., 2021. p. 661-666 (Proceedings of the IEEE Conference on Decision and Control; Vol. 2021-December).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Blood Glucose Regulation in Patients with Type 1 Diabetes Mellitus

T2 - 60th IEEE Conference on Decision and Control, CDC 2021

AU - Franco, Roberto

AU - Rios, Hector

AU - De Loza, Alejandra Ferreira

AU - Efimov, Denis

AU - Cassany, Louis

AU - Gucik-Derigny, David

AU - Cieslak, Jerome

AU - Henry, David

PY - 2021

Y1 - 2021

N2 - This paper deals with the problem of robust blood glucose regulation in critically ill patients affected by type 1 diabetes mellitus. The blood glucose measurement and insulin infusion are intravenous. The proposed algorithm regulates blood glucose and keeps it in the normoglycemia range, i.e., 70-180 mg/dl. To this aim, a control law is proposed based on a Nonlinear Model Reference Adaptive Control approach. The algorithm is composed of nonlinear adaptive gains that ensure convergence to zero of the regulation error. The approach is validated in the UVA/Padova metabolic simulator for ten in silico adult patients with unannounced meals. The results perform well and have minimal risk of hyperglycemic and hypoglycemic events.

AB - This paper deals with the problem of robust blood glucose regulation in critically ill patients affected by type 1 diabetes mellitus. The blood glucose measurement and insulin infusion are intravenous. The proposed algorithm regulates blood glucose and keeps it in the normoglycemia range, i.e., 70-180 mg/dl. To this aim, a control law is proposed based on a Nonlinear Model Reference Adaptive Control approach. The algorithm is composed of nonlinear adaptive gains that ensure convergence to zero of the regulation error. The approach is validated in the UVA/Padova metabolic simulator for ten in silico adult patients with unannounced meals. The results perform well and have minimal risk of hyperglycemic and hypoglycemic events.

KW - Adaptive Control

KW - Blood Glucose Regulation

KW - Diabetes Mellitus Type 1

UR - http://www.scopus.com/inward/record.url?scp=85126012037&partnerID=8YFLogxK

U2 - 10.1109/CDC45484.2021.9683408

DO - 10.1109/CDC45484.2021.9683408

M3 - Contribución a la conferencia

AN - SCOPUS:85126012037

T3 - Proceedings of the IEEE Conference on Decision and Control

SP - 661

EP - 666

BT - 60th IEEE Conference on Decision and Control, CDC 2021

PB - Institute of Electrical and Electronics Engineers Inc.

Y2 - 13 December 2021 through 17 December 2021

ER -

Franco R, Rios H, De Loza AF, Efimov D, Cassany L, Gucik-Derigny D et al. Blood Glucose Regulation in Patients with Type 1 Diabetes Mellitus: A Robust MRAC Approach. In 60th IEEE Conference on Decision and Control, CDC 2021. Institute of Electrical and Electronics Engineers Inc. 2021. p. 661-666. (Proceedings of the IEEE Conference on Decision and Control). doi: 10.1109/CDC45484.2021.9683408

Blood Glucose Regulation in Patients with Type 1 Diabetes Mellitus: A Robust MRAC Approach

Abstract

Publication series

Conference

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this