Abstract
The ethanol extract of the plant Hippocratea excelsa was examined for its anti-inflammatory effects using several animal models. It produced significant inhibition of carrageenan-induced paw edema and reduced the weight of cotton pellet-induced granuloma at doses of 25-100 mg/kg. The extract was found to exert a protective effect on heat-induced erythrocyte lysis at concentrations of 25, 50 and 100 μg/ml. In chronic models of formaldehyde and adjuvant arthritis, its anti-arthritic activity was found to be less than that of phenylbutazone (PNB). It may be inferred that the ethanol extract is effective against both exudative-proliferative and chronic phases of inflammation.
Original language | English |
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Pages (from-to) | 85-90 |
Number of pages | 6 |
Journal | Journal of Ethnopharmacology |
Volume | 47 |
Issue number | 2 |
DOIs | |
State | Published - 7 Jul 1995 |
Externally published | Yes |
Keywords
- Anti-inflammatory activity
- Hippocratea excelsa