A facile synthesis of two brucine-steroid derivatives

Lauro Figueroa-Valverde, Francisco Díaz-Cedillo, Elodia Garcia-Cervera, Maria Lopez-Ramos, Eduardo Pool-Gomez

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Abstract

In this study, two brucine-steroid derivative were synthesized. In first stage, the brucine-androsterone derivative was development by the reaction of N1-(2,3-dimethoxystrychnidin-10-yliden)-ethane-1,2-diamine and androsteronehemisuccinate using as catalyst a carbodiimide derivative. The second stage was achieved by the reaction of N1-(2,3-dimethoxystrychnidin-10- yliden)-ethane-1,2-diamine with b-estradiol 17-hemisuccinate to form the brucine-estradiol conjugatein presence of a carbodiimide derivative.In conclusion, in this study we show a facile procedure for synthesis of two brucine-steroid derivatives.
Original languageAmerican English
Pages (from-to)1901-1904
Number of pages1710
JournalAsian Journal of Chemistry
StatePublished - 25 Mar 2013

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ethylenediamine
Steroids
Derivatives
Carbodiimides
Estradiol
Androsterone
brucine
Catalysts

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Figueroa-Valverde, L., Díaz-Cedillo, F., Garcia-Cervera, E., Lopez-Ramos, M., & Pool-Gomez, E. (2013). A facile synthesis of two brucine-steroid derivatives. Asian Journal of Chemistry, 1901-1904.
Figueroa-Valverde, Lauro ; Díaz-Cedillo, Francisco ; Garcia-Cervera, Elodia ; Lopez-Ramos, Maria ; Pool-Gomez, Eduardo. / A facile synthesis of two brucine-steroid derivatives. In: Asian Journal of Chemistry. 2013 ; pp. 1901-1904.
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Figueroa-Valverde, L, Díaz-Cedillo, F, Garcia-Cervera, E, Lopez-Ramos, M & Pool-Gomez, E 2013, 'A facile synthesis of two brucine-steroid derivatives', Asian Journal of Chemistry, pp. 1901-1904.

A facile synthesis of two brucine-steroid derivatives. / Figueroa-Valverde, Lauro; Díaz-Cedillo, Francisco; Garcia-Cervera, Elodia; Lopez-Ramos, Maria; Pool-Gomez, Eduardo.

In: Asian Journal of Chemistry, 25.03.2013, p. 1901-1904.

Research output: Contribution to journalArticle

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AU - Figueroa-Valverde, Lauro

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AU - Pool-Gomez, Eduardo

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AB - In this study, two brucine-steroid derivative were synthesized. In first stage, the brucine-androsterone derivative was development by the reaction of N1-(2,3-dimethoxystrychnidin-10-yliden)-ethane-1,2-diamine and androsteronehemisuccinate using as catalyst a carbodiimide derivative. The second stage was achieved by the reaction of N1-(2,3-dimethoxystrychnidin-10- yliden)-ethane-1,2-diamine with b-estradiol 17-hemisuccinate to form the brucine-estradiol conjugatein presence of a carbodiimide derivative.In conclusion, in this study we show a facile procedure for synthesis of two brucine-steroid derivatives.

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Figueroa-Valverde L, Díaz-Cedillo F, Garcia-Cervera E, Lopez-Ramos M, Pool-Gomez E. A facile synthesis of two brucine-steroid derivatives. Asian Journal of Chemistry. 2013 Mar 25;1901-1904.