TY - JOUR
T1 - A facile synthesis of two brucine-steroid derivatives
AU - Figueroa-Valverde, Lauro
AU - Díaz-Cedillo, Francisco
AU - Garcia-Cervera, Elodia
AU - Lopez-Ramos, Maria
AU - Pool-Gomez, Eduardo
PY - 2013
Y1 - 2013
N2 - In this study, two brucine-steroid derivative were synthesized. In first stage, the brucine-androsterone derivative was development by the reaction of N1-(2,3-dimethoxystrychnidin-10-yliden)-ethane-1,2-diamine and androsteronehemisuccinate using as catalyst a carbodiimide derivative. The second stage was achieved by the reaction of N1-(2,3-dimethoxystrychnidin-10- yliden)-ethane-1,2-diamine with b-estradiol 17-hemisuccinate to form the brucine-estradiol conjugatein presence of a carbodiimide derivative.In conclusion, in this study we show a facile procedure for synthesis of two brucine-steroid derivatives.
AB - In this study, two brucine-steroid derivative were synthesized. In first stage, the brucine-androsterone derivative was development by the reaction of N1-(2,3-dimethoxystrychnidin-10-yliden)-ethane-1,2-diamine and androsteronehemisuccinate using as catalyst a carbodiimide derivative. The second stage was achieved by the reaction of N1-(2,3-dimethoxystrychnidin-10- yliden)-ethane-1,2-diamine with b-estradiol 17-hemisuccinate to form the brucine-estradiol conjugatein presence of a carbodiimide derivative.In conclusion, in this study we show a facile procedure for synthesis of two brucine-steroid derivatives.
KW - 17-β-Estradiol
KW - Androsterone
KW - Brucine
KW - Carbodiimide
UR - http://www.scopus.com/inward/record.url?scp=84875130825&partnerID=8YFLogxK
U2 - 10.14233/ajchem.2013.13214
DO - 10.14233/ajchem.2013.13214
M3 - Artículo
SN - 0970-7077
VL - 25
SP - 1901
EP - 1904
JO - Asian Journal of Chemistry
JF - Asian Journal of Chemistry
IS - 4
ER -