TY - JOUR
T1 - VNTR polymorphisms of the IL-4 and IL-1RN genes and their relationship with frailty syndrome in Mexican community-dwelling elderly
AU - Pérez-Suárez, Thalía Gabriela
AU - Gutiérrez-Robledo, Luis Miguel
AU - Ávila-Funes, José Alberto
AU - Acosta, José Luis
AU - Escamilla-Tilch, Mónica
AU - Padilla-Gutiérrez, Jorge Ramón
AU - Torres-Carrillo, Norma
AU - Torres-Castro, Sara
AU - López-Ortega, Mariana
AU - Muñoz-Valle, José Francisco
AU - Torres-Carrillo, Nora Magdalena
N1 - Publisher Copyright:
© 2015, Springer International Publishing Switzerland.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Inflammation is a key event that is closely associated with the pathophysiology of frailty. The relationship of genetic polymorphisms into inflammatory cytokines with frailty remains poorly understood. The aim of this study was to investigate the association between VNTR polymorphisms of the IL-4 and IL-1RN genes with the risk of frailty. We included a sample of 630 community-dwelling elderly aged 70 and older. Both IL-4 and IL-1RN VNTR polymorphisms were genotyped by the polymerase chain reaction (PCR) method. Mean age was 77.7 years (SD = 6.0) and 52.5 % were women. The participants classified as frail were more likely to be older, had lower MMSE score (p < 0.001), and had more disability for IADL (p < 0.001) and ADL (p < 0.001). Genotypic and allelic frequencies for the IL-4 VNTR polymorphism did not show significant differences between study groups (p > 0.05). However, we just observed a significant difference in the allelic frequencies for the A2 allele of the IL-1RN VNTR polymorphism between frail and nonfrail groups (OR 1.84, 95 % CI 1.08–3.12, p = 0.02). In addition, we analyzed the combined effect of the IL-4 and IL-1RN VNTR polymorphisms and their possible association with frailty, where the combined IL-4low–IL-1Rahigh genotype was identified as a marker of risk to frailty syndrome (OR 7.86, 95 % CI 1.83–33.69, p = 0.006). Our results suggest that both A2 allele and the combined IL-4low–IL-1Rahigh genotype might be genetic markers of susceptibility to frailty in Mexican elderly.
AB - Inflammation is a key event that is closely associated with the pathophysiology of frailty. The relationship of genetic polymorphisms into inflammatory cytokines with frailty remains poorly understood. The aim of this study was to investigate the association between VNTR polymorphisms of the IL-4 and IL-1RN genes with the risk of frailty. We included a sample of 630 community-dwelling elderly aged 70 and older. Both IL-4 and IL-1RN VNTR polymorphisms were genotyped by the polymerase chain reaction (PCR) method. Mean age was 77.7 years (SD = 6.0) and 52.5 % were women. The participants classified as frail were more likely to be older, had lower MMSE score (p < 0.001), and had more disability for IADL (p < 0.001) and ADL (p < 0.001). Genotypic and allelic frequencies for the IL-4 VNTR polymorphism did not show significant differences between study groups (p > 0.05). However, we just observed a significant difference in the allelic frequencies for the A2 allele of the IL-1RN VNTR polymorphism between frail and nonfrail groups (OR 1.84, 95 % CI 1.08–3.12, p = 0.02). In addition, we analyzed the combined effect of the IL-4 and IL-1RN VNTR polymorphisms and their possible association with frailty, where the combined IL-4low–IL-1Rahigh genotype was identified as a marker of risk to frailty syndrome (OR 7.86, 95 % CI 1.83–33.69, p = 0.006). Our results suggest that both A2 allele and the combined IL-4low–IL-1Rahigh genotype might be genetic markers of susceptibility to frailty in Mexican elderly.
KW - Frailty
KW - Genetic susceptibility
KW - IL-1RN
KW - IL-4
KW - Older adults
KW - VNTR polymorphism
UR - http://www.scopus.com/inward/record.url?scp=84949496751&partnerID=8YFLogxK
U2 - 10.1007/s40520-015-0503-4
DO - 10.1007/s40520-015-0503-4
M3 - Artículo
C2 - 26646252
AN - SCOPUS:84949496751
SN - 1594-0667
VL - 28
SP - 823
EP - 832
JO - Aging Clinical and Experimental Research
JF - Aging Clinical and Experimental Research
IS - 5
ER -