TY - JOUR
T1 - Updated view of tars for psoriasis
T2 - what have we learned over the last decade?
AU - Ávalos-Viveros, Miguel
AU - Esquivel-García, Roberto
AU - García-Pérez, Manuel
AU - Torres-García, Enelio
AU - Bartolomé-Camacho, María Carmen
AU - Santes, Víctor
AU - García-Pérez, Martha Estrella
N1 - Publisher Copyright:
© 2022 the International Society of Dermatology.
PY - 2023/3
Y1 - 2023/3
N2 - Tars are one of the most effective, unknown, and oldest therapies for psoriasis. They include coal tar (CT) and biomass-derived products. These treatments, particularly the CT, have proven to be cost-effective with long remission times compared to other systemic or topical treatments. However, they have hardly evolved in recent years, as they are not well-embraced by clinicians or patients because of concerns regarding cosmesis and safety. This review summarizes current knowledge about the chemical characterization, mechanism of action, toxicity, and clinical studies supporting the use of tars for psoriasis over the last decade. Trends within these above aspects are reviewed, and avenues of research are identified. CT is rich in polycyclic aromatic hydrocarbons, whereas biomass-derived tars are rich in phenols. While the activation of the aryl hydrocarbon receptor is involved in the antipsoriatic effect of CT, the mechanism of action of biomass-derived products remains to be elucidated. No conclusive evidence exists about the risk of cancer in psoriasis patients under CT treatment. Large, randomized, double-blind, controlled clinical trials are necessary to promote the inclusion of tars as part of modern therapies for psoriasis.
AB - Tars are one of the most effective, unknown, and oldest therapies for psoriasis. They include coal tar (CT) and biomass-derived products. These treatments, particularly the CT, have proven to be cost-effective with long remission times compared to other systemic or topical treatments. However, they have hardly evolved in recent years, as they are not well-embraced by clinicians or patients because of concerns regarding cosmesis and safety. This review summarizes current knowledge about the chemical characterization, mechanism of action, toxicity, and clinical studies supporting the use of tars for psoriasis over the last decade. Trends within these above aspects are reviewed, and avenues of research are identified. CT is rich in polycyclic aromatic hydrocarbons, whereas biomass-derived tars are rich in phenols. While the activation of the aryl hydrocarbon receptor is involved in the antipsoriatic effect of CT, the mechanism of action of biomass-derived products remains to be elucidated. No conclusive evidence exists about the risk of cancer in psoriasis patients under CT treatment. Large, randomized, double-blind, controlled clinical trials are necessary to promote the inclusion of tars as part of modern therapies for psoriasis.
KW - coal tar
KW - pine tar
KW - psoriasis
KW - safety
UR - http://www.scopus.com/inward/record.url?scp=85127704692&partnerID=8YFLogxK
U2 - 10.1111/ijd.16193
DO - 10.1111/ijd.16193
M3 - Artículo de revisión
C2 - 35398899
AN - SCOPUS:85127704692
SN - 0011-9059
VL - 62
SP - 290
EP - 301
JO - International Journal of Dermatology
JF - International Journal of Dermatology
IS - 3
ER -