TY - JOUR
T1 - Undaria pinnatifida and fucoxanthin ameliorate lipogenesis and markers of both inflammation and cardiovascular dysfunction in an animal model of diet-induced obesity
AU - Grasa-López, Ameyalli
AU - Miliar-García, Ángel
AU - Quevedo-Corona, Lucía
AU - Paniagua-Castro, Norma
AU - Escalona-Cardoso, Gerardo
AU - Reyes-Maldonado, Elba
AU - Jaramillo-Flores, María Eugenia
N1 - Publisher Copyright:
© 2016 by the authors; licensee MDPI.
PY - 2016/8
Y1 - 2016/8
N2 - Brown algae and its carotenoids have been shown to have a positive influence on obesity and its comorbidities. This study evaluated the effect of Undaria pinnatifida and fucoxanthin on biochemical, physiological and inflammation markers related to obesity and on the expression of genes engaged on white adipose tissue lipid metabolism in a murine model of diet-induced obesity. The treatments improved energy expenditure, β-oxidation and adipogenesis by upregulating PPARα, PGC1α, PPARγ and UCP-1. Adipogenesis was also confirmed by image analysis of the retroperitoneal adipose tissue, by measuring cell area, perimeter and cellular density. Additionally, the treatments, ameliorated adipose tissue accumulation, insulin resistance, blood pressure, cholesterol and triglycerides concentration in serum, and reduced lipogenesis and inflammation by downregulating acetyl-CoA carboxylase (ACC) gene expression, increasing serum concentration and expression of adiponectin as well as downregulating IL-6 expression. Both fucoxanthin and Undaria pinnatifida may be considered for treating obesity and other diseases related.
AB - Brown algae and its carotenoids have been shown to have a positive influence on obesity and its comorbidities. This study evaluated the effect of Undaria pinnatifida and fucoxanthin on biochemical, physiological and inflammation markers related to obesity and on the expression of genes engaged on white adipose tissue lipid metabolism in a murine model of diet-induced obesity. The treatments improved energy expenditure, β-oxidation and adipogenesis by upregulating PPARα, PGC1α, PPARγ and UCP-1. Adipogenesis was also confirmed by image analysis of the retroperitoneal adipose tissue, by measuring cell area, perimeter and cellular density. Additionally, the treatments, ameliorated adipose tissue accumulation, insulin resistance, blood pressure, cholesterol and triglycerides concentration in serum, and reduced lipogenesis and inflammation by downregulating acetyl-CoA carboxylase (ACC) gene expression, increasing serum concentration and expression of adiponectin as well as downregulating IL-6 expression. Both fucoxanthin and Undaria pinnatifida may be considered for treating obesity and other diseases related.
KW - Adipose tissue expansion
KW - Energy expenditure
KW - Fucoxanthin
KW - Gene expression
KW - Inflammation
KW - Obesity
KW - Undaria pinnatifida
UR - http://www.scopus.com/inward/record.url?scp=84984923574&partnerID=8YFLogxK
U2 - 10.3390/md14080148
DO - 10.3390/md14080148
M3 - Artículo
C2 - 27527189
SN - 1660-3397
VL - 14
JO - Marine Drugs
JF - Marine Drugs
IS - 8
M1 - 148
ER -