TY - JOUR
T1 - Tibolone Prevents Oxidation and Ameliorates Cholinergic Deficit Induced by Ozone Exposure in the Male Rat Hippocampus
AU - Farfán-García, E. D.
AU - Castillo-Hernández, M. C.
AU - Pinto-Almazán, R.
AU - Rivas-Arancibia, S.
AU - Gallardo, J. M.
AU - Guerra-Araiza, C.
N1 - Publisher Copyright:
© 2014, Springer Science+Business Media New York.
PY - 2014/9
Y1 - 2014/9
N2 - Oxidative stress is related to the development of central nervous system diseases involving memory processes. Cholinergic system and memory processes are disrupted by ozone exposure. In rats, ozone induces motor disturbances and memory deficits as well as biochemical changes in brain regions related to memory processes. In this work, we analyzed the effect of chronic tibolone (TIB) administration in central nervous system, specifically the content of choline acetyltransferase, acetylcholinesterase, acetylcholine and oxidative stress markers in the hippocampus of male rats exposed to ozone. Our results reveal a neuroprotective effect of TIB treatment on neuronal damage induced by chronic ozone exposure. Furthermore, we suggest that TIB can prevent memory deficits by providing a protective effect against oxidative stress and the cholinergic system disruption induced by ozone exposure. Together, these findings present a potential neuroprotective effect of TIB in processes linked to memory deficits induced by aging or neurodegenerative diseases.
AB - Oxidative stress is related to the development of central nervous system diseases involving memory processes. Cholinergic system and memory processes are disrupted by ozone exposure. In rats, ozone induces motor disturbances and memory deficits as well as biochemical changes in brain regions related to memory processes. In this work, we analyzed the effect of chronic tibolone (TIB) administration in central nervous system, specifically the content of choline acetyltransferase, acetylcholinesterase, acetylcholine and oxidative stress markers in the hippocampus of male rats exposed to ozone. Our results reveal a neuroprotective effect of TIB treatment on neuronal damage induced by chronic ozone exposure. Furthermore, we suggest that TIB can prevent memory deficits by providing a protective effect against oxidative stress and the cholinergic system disruption induced by ozone exposure. Together, these findings present a potential neuroprotective effect of TIB in processes linked to memory deficits induced by aging or neurodegenerative diseases.
KW - Cholinergic system
KW - Hormone replacement therapy
KW - Male rat
KW - Memory
KW - Oxidative stress
KW - Tibolone
UR - http://www.scopus.com/inward/record.url?scp=84939871666&partnerID=8YFLogxK
U2 - 10.1007/s11064-014-1385-0
DO - 10.1007/s11064-014-1385-0
M3 - Artículo
SN - 0364-3190
VL - 39
SP - 1776
EP - 1786
JO - Neurochemical Research
JF - Neurochemical Research
IS - 9
ER -