TY - JOUR
T1 - The role of xenobiotic-metabolizing enzymes in the placenta
T2 - a growing research field
AU - RIVA-TREM
AU - Blanco-Castañeda, Ricardo
AU - Galaviz-Hernández, Carlos
AU - Souto, Paula C.S.
AU - Lima, Victor Vitorino
AU - Giachini, Fernanda R.
AU - Escudero, Carlos
AU - Damiano, Alicia E.
AU - Barragán-Zúñiga, L. Jazel
AU - Martínez-Aguilar, Gerardo
AU - Sosa-Macías, Martha
N1 - Publisher Copyright:
© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020/3/3
Y1 - 2020/3/3
N2 - Introduction: The placenta is a temporary and unique organ that allows for the physical connection between a mother and fetus; this organ regulates the transport of gases and nutrients mediating the elimination of waste products contained in the fetal circulation. The placenta performs metabolic and excretion functions, on the basis of multiple enzymatic systems responsible for the oxidation, reduction, hydrolysis, and conjugation of xenobiotics. These mechanisms give the placenta a protective role that limits the fetal exposure to harmful compounds. During pregnancy, some diseases require uninterrupted treatment even if it is detrimental to the fetus. Drugs and other xenobiotics alter gene expression in the placenta with repercussions for the fetus and mother’s well-being. Areas covered: This review provides a brief description of the human placental structure and function, the main drug and xenobiotic transporters and metabolizing enzymes, placenta-metabolized substrates, and alterations in gene expression that the exposure to xenobiotics may cause. Expert opinion: Research should be focused on the identification and validation of biological markers for the assessment of the harmful effects of some drugs in pregnancy, including the evaluation of polymorphisms and methylation patterns in chorionic villous samples and/or amniotic fluid.
AB - Introduction: The placenta is a temporary and unique organ that allows for the physical connection between a mother and fetus; this organ regulates the transport of gases and nutrients mediating the elimination of waste products contained in the fetal circulation. The placenta performs metabolic and excretion functions, on the basis of multiple enzymatic systems responsible for the oxidation, reduction, hydrolysis, and conjugation of xenobiotics. These mechanisms give the placenta a protective role that limits the fetal exposure to harmful compounds. During pregnancy, some diseases require uninterrupted treatment even if it is detrimental to the fetus. Drugs and other xenobiotics alter gene expression in the placenta with repercussions for the fetus and mother’s well-being. Areas covered: This review provides a brief description of the human placental structure and function, the main drug and xenobiotic transporters and metabolizing enzymes, placenta-metabolized substrates, and alterations in gene expression that the exposure to xenobiotics may cause. Expert opinion: Research should be focused on the identification and validation of biological markers for the assessment of the harmful effects of some drugs in pregnancy, including the evaluation of polymorphisms and methylation patterns in chorionic villous samples and/or amniotic fluid.
KW - CYP450 enzyme
KW - drug
KW - gene expression
KW - placenta
KW - placental metabolism
KW - pregnancy
KW - transport protein
UR - http://www.scopus.com/inward/record.url?scp=85080917461&partnerID=8YFLogxK
U2 - 10.1080/17512433.2020.1733412
DO - 10.1080/17512433.2020.1733412
M3 - Artículo de revisión
C2 - 32129110
AN - SCOPUS:85080917461
SN - 1751-2433
VL - 13
SP - 247
EP - 263
JO - Expert Review of Clinical Pharmacology
JF - Expert Review of Clinical Pharmacology
IS - 3
ER -