TY - JOUR
T1 - The role of autophagy in bacterial infections
AU - Castrejón-Jiménez, Nayeli Shantal
AU - Leyva-Paredes, Kahiry
AU - Hernández-González, Juan Carlos
AU - Luna-Herrera, Julieta
AU - García-Pérez, Blanca Estela
PY - 2015
Y1 - 2015
N2 - Autophagy is a highly conserved catabolic process for the degradation of cytosolic components including damaged organelles, protein aggregates, and intracellular bacteria through a lysosome-dependent pathway. Autophagy can be induced in response to stress conditions. Furthermore, autophagy has been described as involved in both innate and adaptive immune responses, and several studies have shown that certain microorganisms can be eliminated by the autophagic route in a process known as xenophagy. However, several pathogens have developed different strategies to evade or exploit autophagy to ensure their survival. Here, we review the role of autophagy in response to bacterial pathogens.
AB - Autophagy is a highly conserved catabolic process for the degradation of cytosolic components including damaged organelles, protein aggregates, and intracellular bacteria through a lysosome-dependent pathway. Autophagy can be induced in response to stress conditions. Furthermore, autophagy has been described as involved in both innate and adaptive immune responses, and several studies have shown that certain microorganisms can be eliminated by the autophagic route in a process known as xenophagy. However, several pathogens have developed different strategies to evade or exploit autophagy to ensure their survival. Here, we review the role of autophagy in response to bacterial pathogens.
KW - Autophagy
KW - Pathogens
KW - Selective autophagy
KW - Xenophagy
UR - http://www.scopus.com/inward/record.url?scp=84936942427&partnerID=8YFLogxK
U2 - 10.5582/bst.2015.01035
DO - 10.5582/bst.2015.01035
M3 - Artículo de revisión
SN - 1881-7815
VL - 9
SP - 149
EP - 159
JO - BioScience Trends
JF - BioScience Trends
IS - 3
ER -