TY - JOUR
T1 - The protective effect of dietary arthrospira (spirulina) maxima against mutagenicity induced by Benzo[alpha]pyrene in mice
AU - Chamorro-Cevallos, Germán
AU - Garduño-Siciliano, Leticia
AU - Martínez-Galero, Elizdath
AU - Mojica-Villegas, Angélica
AU - Pages, Nicole
AU - Gutiérrez-Salmeán, Gabriela
PY - 2014/5/1
Y1 - 2014/5/1
N2 - Benzo[alpha]pyrene (B[α]P) was used to test the possible antimutagenic effects of Arthrospira (Spirulina) maxima (SP) on male and female mice. SP was orally administered at 0, 200, 400, or 800mg/kg of body weight to animals of both sexes for 2 weeks before starting the B[α]P (intraperitoneal injection) at 125mg/kg of body weight for 5 consecutive days. For the male dominant lethal test, each male was caged with two untreated females per week for 3 weeks. For the female dominant lethal test, each female was caged for 1 week with one untreated male. All the females were evaluated 13-15 days after mating for incidence of pregnancy, total corpora lutea, total implants and pre- and postimplant losses. SP protected from B[α]P-induced pre- and postimplant losses in the male dominant lethal test, and from B[α]P-induced postimplantation losses in treated females. Moreover, SP treatment significantly reduced the detrimental effect of B[α]P on the quality of mouse semen. Our results illustrate the protective effects of SP in relation to B[α]P-induced genetic damage to germ cells. We conclude that SP, owing mainly to the presence of phycocyanin, could be of potential clinical interest in cancer treatment or prevention of relapse.
AB - Benzo[alpha]pyrene (B[α]P) was used to test the possible antimutagenic effects of Arthrospira (Spirulina) maxima (SP) on male and female mice. SP was orally administered at 0, 200, 400, or 800mg/kg of body weight to animals of both sexes for 2 weeks before starting the B[α]P (intraperitoneal injection) at 125mg/kg of body weight for 5 consecutive days. For the male dominant lethal test, each male was caged with two untreated females per week for 3 weeks. For the female dominant lethal test, each female was caged for 1 week with one untreated male. All the females were evaluated 13-15 days after mating for incidence of pregnancy, total corpora lutea, total implants and pre- and postimplant losses. SP protected from B[α]P-induced pre- and postimplant losses in the male dominant lethal test, and from B[α]P-induced postimplantation losses in treated females. Moreover, SP treatment significantly reduced the detrimental effect of B[α]P on the quality of mouse semen. Our results illustrate the protective effects of SP in relation to B[α]P-induced genetic damage to germ cells. We conclude that SP, owing mainly to the presence of phycocyanin, could be of potential clinical interest in cancer treatment or prevention of relapse.
KW - anticancer
KW - antigenotoxic
KW - antioxidant
KW - blue-green algae
KW - cyanobacterium
UR - http://www.scopus.com/inward/record.url?scp=84900560148&partnerID=8YFLogxK
U2 - 10.1089/jmf.2013.0109
DO - 10.1089/jmf.2013.0109
M3 - Artículo
C2 - 24787733
SN - 1096-620X
VL - 17
SP - 527
EP - 534
JO - Journal of Medicinal Food
JF - Journal of Medicinal Food
IS - 5
ER -