TY - JOUR
T1 - The potential role of sesquiterpene lactones isolated from medicinal plants in the treatment of the metabolic syndrome – A review
AU - Salazar-Gómez, Anuar
AU - Ontiveros-Rodríguez, Julio C.
AU - Pablo-Pérez, Saudy S.
AU - Vargas-Díaz, M. Elena
AU - Garduño-Siciliano, Leticia
N1 - Publisher Copyright:
© 2020 SAAB
PY - 2020/12
Y1 - 2020/12
N2 - Metabolic syndrome comprises a cluster of metabolic disorders related to the development of cardiovascular disease and type 2 diabetes mellitus. In latter years, plant secondary metabolites have become of special interest because of their potential role in preventing and managing metabolic syndrome. Sesquiterpene lactones constitute a large and diverse group of biologically active compounds widely distributed in several medicinal plants used for the treatment of metabolic disorders. The structural diversity and the broad spectrum of biological activities of these compounds drew significant interests in the pharmacological applications. This review describes selected sesquiterpene lactones that have been experimentally validated for their biological activities related to risk factors of metabolic syndrome, together with their mechanisms of action. The potential beneficial effects of sesquiterpene lactones discussed in this review demonstrate that these substances represent remarkable compounds with a diversity of molecular structure and high biological activity, providing new insights into the possible role in metabolic syndrome management.
AB - Metabolic syndrome comprises a cluster of metabolic disorders related to the development of cardiovascular disease and type 2 diabetes mellitus. In latter years, plant secondary metabolites have become of special interest because of their potential role in preventing and managing metabolic syndrome. Sesquiterpene lactones constitute a large and diverse group of biologically active compounds widely distributed in several medicinal plants used for the treatment of metabolic disorders. The structural diversity and the broad spectrum of biological activities of these compounds drew significant interests in the pharmacological applications. This review describes selected sesquiterpene lactones that have been experimentally validated for their biological activities related to risk factors of metabolic syndrome, together with their mechanisms of action. The potential beneficial effects of sesquiterpene lactones discussed in this review demonstrate that these substances represent remarkable compounds with a diversity of molecular structure and high biological activity, providing new insights into the possible role in metabolic syndrome management.
KW - Antidiabetic
KW - Hypoglycemic
KW - Hypolipidemic
KW - Medicinal plants
KW - Metabolic syndrome
KW - Sesquiterpene lactones
UR - http://www.scopus.com/inward/record.url?scp=85090915793&partnerID=8YFLogxK
U2 - 10.1016/j.sajb.2020.08.020
DO - 10.1016/j.sajb.2020.08.020
M3 - Artículo de revisión
AN - SCOPUS:85090915793
SN - 0254-6299
VL - 135
SP - 240
EP - 251
JO - South African Journal of Botany
JF - South African Journal of Botany
ER -