TY - JOUR
T1 - The last decade of solvent research in animal models of abuse
T2 - Mechanistic and behavioral studies
AU - Bowen, Scott E.
AU - Batis, Jeffery C.
AU - Paez-Martinez, Nayeli
AU - Cruz, Silvia L.
N1 - Funding Information:
Supported in part by NIDA grants R01DA15095 and R01DA015951 to SEB and grant 43604-M to SLC from Conacyt, Mexico.
PY - 2006/11
Y1 - 2006/11
N2 - The Last Decade of Animal solvent Abuse Research: Mechanistic and Behavioral Studies. Bowen, S. E., Batis, J.C., Paez-Martinez, N., and Cruz, S.L. Neurotoxicology and Teratology, XX, 2006. The abuse of volatile organic solvents (inhalants) leads to diverse sequelae at levels ranging from the cell to the whole organism. This paper reviews findings from the last 10 years of animal models investigating the behavioral and mechanistic effects of solvent abuse. In research with animal models of inhalant abuse, NMDA, GABAA, glycine, nicotine, and 5HT3 receptors appear to be important targets of action for several abused solvents with emerging evidence suggesting that other receptor subtypes and nerve membrane ion channels may be involved as well. The behavioral effects vary in magnitude and duration among the solvents investigated. The behavioral effects of acute and chronic inhalant abuse include motor impairment, alterations in spontaneous motor activity, anticonvulsant effects, anxiolytic effects, sensory effects, and effects on learning, memory and operant behavior (e.g., response rates and discriminative stimulus effects). In addition, repeated exposure to these solvents may produce tolerance, dependence and/or sensitization to these effects.
AB - The Last Decade of Animal solvent Abuse Research: Mechanistic and Behavioral Studies. Bowen, S. E., Batis, J.C., Paez-Martinez, N., and Cruz, S.L. Neurotoxicology and Teratology, XX, 2006. The abuse of volatile organic solvents (inhalants) leads to diverse sequelae at levels ranging from the cell to the whole organism. This paper reviews findings from the last 10 years of animal models investigating the behavioral and mechanistic effects of solvent abuse. In research with animal models of inhalant abuse, NMDA, GABAA, glycine, nicotine, and 5HT3 receptors appear to be important targets of action for several abused solvents with emerging evidence suggesting that other receptor subtypes and nerve membrane ion channels may be involved as well. The behavioral effects vary in magnitude and duration among the solvents investigated. The behavioral effects of acute and chronic inhalant abuse include motor impairment, alterations in spontaneous motor activity, anticonvulsant effects, anxiolytic effects, sensory effects, and effects on learning, memory and operant behavior (e.g., response rates and discriminative stimulus effects). In addition, repeated exposure to these solvents may produce tolerance, dependence and/or sensitization to these effects.
KW - Animal models
KW - Behavior
KW - Inhalants
KW - Mechanisms of action
KW - Toluene
KW - Volatile organic solvents
UR - http://www.scopus.com/inward/record.url?scp=33751546329&partnerID=8YFLogxK
U2 - 10.1016/j.ntt.2006.09.005
DO - 10.1016/j.ntt.2006.09.005
M3 - Artículo de revisión
SN - 0892-0362
VL - 28
SP - 636
EP - 647
JO - Neurotoxicology and Teratology
JF - Neurotoxicology and Teratology
IS - 6
ER -