TY - JOUR
T1 - The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus
AU - García-Machorro, Jazmín
AU - Ramírez-Salinas, Gema Lizbeth
AU - Martinez-Archundia, Marlet
AU - Correa-Basurto, José
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/11
Y1 - 2022/11
N2 - After the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants challenge researchers to develop new pharmacological or preventive strategies. However, vaccines still represent an efficient way to control the SARS-CoV-2 pandemic worldwide. This review describes the importance of bioinformatic and immunoinformatic tools (in silico) for guide vaccine design. In silico strategies permit the identification of epitopes (immunogenic peptides) which could be used as potential vaccines, as well as nonacarriers such as: vector viral based vaccines, RNA-based vaccines and dendrimers through immunoinformatics. Currently, nucleic acid and protein sequential as well structural analyses through bioinformatic tools allow us to get immunogenic epitopes which can induce immune response alone or in complex with nanocarriers. One of the advantages of in silico techniques is that they facilitate the identification of epitopes, while accelerating the process and helping to economize some stages of the development of safe vaccines.
AB - After the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants challenge researchers to develop new pharmacological or preventive strategies. However, vaccines still represent an efficient way to control the SARS-CoV-2 pandemic worldwide. This review describes the importance of bioinformatic and immunoinformatic tools (in silico) for guide vaccine design. In silico strategies permit the identification of epitopes (immunogenic peptides) which could be used as potential vaccines, as well as nonacarriers such as: vector viral based vaccines, RNA-based vaccines and dendrimers through immunoinformatics. Currently, nucleic acid and protein sequential as well structural analyses through bioinformatic tools allow us to get immunogenic epitopes which can induce immune response alone or in complex with nanocarriers. One of the advantages of in silico techniques is that they facilitate the identification of epitopes, while accelerating the process and helping to economize some stages of the development of safe vaccines.
KW - COVID-19
KW - SARS-CoV-2
KW - bioinformatics
KW - epitope
KW - immunoinformatics
KW - vaccine
UR - http://www.scopus.com/inward/record.url?scp=85141800340&partnerID=8YFLogxK
U2 - 10.3390/vaccines10111844
DO - 10.3390/vaccines10111844
M3 - Artículo de revisión
C2 - 36366353
AN - SCOPUS:85141800340
SN - 2076-393X
VL - 10
JO - Vaccines
JF - Vaccines
IS - 11
M1 - 1844
ER -