TY - JOUR
T1 - Synthesis of demethylated nidulol via an intramolecular Michael reaction
AU - Jiménez, Rogelio
AU - Maldonado, Luís A.
AU - Salgado-Zamora, Héctor
PY - 2010/8
Y1 - 2010/8
N2 - An expeditious synthesis of 5,7-dihydroxy-6-methylphthalide from open-chain precursors is described. The key intermediates, synthons 3 and 4, were readily obtained from accessible materials and were further transformed to a common precursor, a five-membered lactone derivative, via an intramolecular Michael addition. Lactone 2 was aromatised to the phthalide system under basic conditions. The process thus constitutes a formal synthesis of the phthalide framework.
AB - An expeditious synthesis of 5,7-dihydroxy-6-methylphthalide from open-chain precursors is described. The key intermediates, synthons 3 and 4, were readily obtained from accessible materials and were further transformed to a common precursor, a five-membered lactone derivative, via an intramolecular Michael addition. Lactone 2 was aromatised to the phthalide system under basic conditions. The process thus constitutes a formal synthesis of the phthalide framework.
KW - intramolecular aromatisation
KW - nidulol
KW - phthalides
UR - http://www.scopus.com/inward/record.url?scp=77954839351&partnerID=8YFLogxK
U2 - 10.1080/14786410903458265
DO - 10.1080/14786410903458265
M3 - Artículo
SN - 1478-6419
VL - 24
SP - 1274
EP - 1281
JO - Natural Product Research
JF - Natural Product Research
IS - 13
ER -