TY - JOUR
T1 - Synthesis, characterization, and preliminary in vitro cytotoxic evaluation of a series of 2-substituted benzo [d] [1,3] azoles
AU - Linares-Anaya, Ozvaldo
AU - Avila-Sorrosa, Alcives
AU - Díaz-Cedillo, Francisco
AU - Gil-Ruiz, Luis Ángel
AU - Correa-Basurto, José
AU - Salazar-Mendoza, Domingo
AU - Orjuela, Adrian L.
AU - Alí-Torres, Jorge
AU - Ramírez-Apan, María Teresa
AU - Morales-Morales, David
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - A series of benzo [d] [1,3] azoles 2-substituted with benzyl-and allyl-sulfanyl groups were synthesized, and their cytotoxic activities were in vitro evaluated against a panel of six human cancer cell lines. The results showed that compounds BTA-1 and BMZ-2 have the best inhibitory effects, compound BMZ-2 being comparable in some cases with the reference drug tamoxifen and exhibiting a low cytotoxic effect against healthy cells. In silico molecular coupling studies at the tamoxifen binding site of ERα and GPER receptors revealed affinity and the possible mode of interaction of both compounds BTA-1 and BMZ-2.
AB - A series of benzo [d] [1,3] azoles 2-substituted with benzyl-and allyl-sulfanyl groups were synthesized, and their cytotoxic activities were in vitro evaluated against a panel of six human cancer cell lines. The results showed that compounds BTA-1 and BMZ-2 have the best inhibitory effects, compound BMZ-2 being comparable in some cases with the reference drug tamoxifen and exhibiting a low cytotoxic effect against healthy cells. In silico molecular coupling studies at the tamoxifen binding site of ERα and GPER receptors revealed affinity and the possible mode of interaction of both compounds BTA-1 and BMZ-2.
KW - 2-substituted benzo [d] [1,3] azoles
KW - Breast cancer
KW - ERα and GPER
KW - In vitro cytotoxicity
KW - Molecular docking
UR - http://www.scopus.com/inward/record.url?scp=85106331630&partnerID=8YFLogxK
U2 - 10.3390/molecules26092780
DO - 10.3390/molecules26092780
M3 - Artículo
C2 - 34066820
AN - SCOPUS:85106331630
SN - 1420-3049
VL - 26
JO - Molecules
JF - Molecules
IS - 9
M1 - 2780
ER -