TY - JOUR
T1 - Surface tailoring for poly(ester-urethane) scaffold via plasma radiation-induced graft polymerization of N-hydroxyethyl acrylamide
AU - Segovia-Hernández, Valentina Alejandra
AU - González-Torres, Maykel
AU - Sánchez-Sánchez, Roberto
AU - Melgarejo-Ramírez, Yaaziel
AU - Ruvalcaba-Paredes, Erika Karina
AU - Leyva-Gómez, Gerardo
AU - Velasquillo, Cristina
AU - Ribas-Aparicio, Rosa María
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - The synthesis of the poly(ester-urethanes) using poly(3-hydroxybutyrate) has gained increasing interest as scaffolds for use in tissue engineering despite their moderate hydrophobicity and biocompatibility. However, it is not yet known if the grafting of poly(N‐hydroxyethyl acrylamide) is suitable to improve the degree of hydrophilicity of the surface. This study aims to tailor the surface of these biopolymers by plasma-induced graft polymerization of N‐hydroxyethyl acrylamide. The synthesized specimens are characterized by Fourier-transform infrared spectroscopy, scanning electron microscope, atomic force microscope, and contact angle measurements. The cell viability and cytotoxicity of the samples are assessed through MTT and live/dead viability/cytotoxicity kit assays with pancreatic islet cells. Our findings suggest that the plasma-induced surface grafting increase the roughness and the wettability, and also improve the cell viability of the starting substrate.
AB - The synthesis of the poly(ester-urethanes) using poly(3-hydroxybutyrate) has gained increasing interest as scaffolds for use in tissue engineering despite their moderate hydrophobicity and biocompatibility. However, it is not yet known if the grafting of poly(N‐hydroxyethyl acrylamide) is suitable to improve the degree of hydrophilicity of the surface. This study aims to tailor the surface of these biopolymers by plasma-induced graft polymerization of N‐hydroxyethyl acrylamide. The synthesized specimens are characterized by Fourier-transform infrared spectroscopy, scanning electron microscope, atomic force microscope, and contact angle measurements. The cell viability and cytotoxicity of the samples are assessed through MTT and live/dead viability/cytotoxicity kit assays with pancreatic islet cells. Our findings suggest that the plasma-induced surface grafting increase the roughness and the wettability, and also improve the cell viability of the starting substrate.
KW - Biomaterials
KW - Plasma
KW - Polyurethanes
KW - Scaffolds
UR - http://www.scopus.com/inward/record.url?scp=85082724869&partnerID=8YFLogxK
U2 - 10.1016/j.matlet.2020.127745
DO - 10.1016/j.matlet.2020.127745
M3 - Artículo
AN - SCOPUS:85082724869
SN - 0167-577X
VL - 270
JO - Materials Letters
JF - Materials Letters
M1 - 127745
ER -