TY - JOUR
T1 - Src, Akt, NF-κB, BCL-2 and c-IAP1 may be involved in an anti-apoptotic effect in patients with BCR-ABL positive and BCR-ABL negative acute lymphoblastic leukemia
AU - Vázquez-Franco, José E.
AU - Reyes-Maldonado, Elba
AU - Vela-Ojeda, Jorge
AU - Domínguez-López, Maria L.
AU - Lezama, Ruth A.
PY - 2012/7
Y1 - 2012/7
N2 - BCR-ABL kinase has been observed to be potentially related to leukemic cell development. Adult patients with acute lymphoblastic leukemia (ALL) were evaluated to determine whether presence/absence of BCR-ABL induced differences in activation of Src, PI3K/Akt and NF-κB or in the expression of anti-apoptotic proteins such as BCL-2 and c-IAP1. BCR-ABL positive patients showed a significantly higher activation of Src and Akt compared with BCR-ABL negative patients and healthy donors. BCR-ABL negative patients also showed a significant activation of Src and low levels of Akt activation compared with healthy donors. Both patient groups had increased NF-κB activation and overexpression of BCL-2 and c-IAP1. This is the first study to evaluate concurrently in ALL patients presence/absence of BCR-ABL in relation to activation of Src, Akt and NF-κB and the expression of anti-apoptotic proteins. Results suggest that these proteins may be involved in an anti-apoptotic signaling pathway.
AB - BCR-ABL kinase has been observed to be potentially related to leukemic cell development. Adult patients with acute lymphoblastic leukemia (ALL) were evaluated to determine whether presence/absence of BCR-ABL induced differences in activation of Src, PI3K/Akt and NF-κB or in the expression of anti-apoptotic proteins such as BCL-2 and c-IAP1. BCR-ABL positive patients showed a significantly higher activation of Src and Akt compared with BCR-ABL negative patients and healthy donors. BCR-ABL negative patients also showed a significant activation of Src and low levels of Akt activation compared with healthy donors. Both patient groups had increased NF-κB activation and overexpression of BCL-2 and c-IAP1. This is the first study to evaluate concurrently in ALL patients presence/absence of BCR-ABL in relation to activation of Src, Akt and NF-κB and the expression of anti-apoptotic proteins. Results suggest that these proteins may be involved in an anti-apoptotic signaling pathway.
KW - Acute lymphoblastic leukemia
KW - Akt
KW - Apoptosis inhibition
KW - BCR-ABL
KW - NF-κB
KW - Src
UR - http://www.scopus.com/inward/record.url?scp=84862322760&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2012.03.020
DO - 10.1016/j.leukres.2012.03.020
M3 - Artículo
C2 - 22591684
SN - 0145-2126
VL - 36
SP - 862
EP - 867
JO - Leukemia Research
JF - Leukemia Research
IS - 7
ER -