TY - JOUR
T1 - Solubilization and anticancer-activity enhancement of Methotrexate by novel dendrimeric nanodevices synthesized in one-step reaction
AU - Soto-Castro, Delia
AU - Cruz-Morales, Jorge A.
AU - Apan, María Teresa Ramírez
AU - Guadarrama, Patricia
N1 - Funding Information:
This research was carried out with the support of Grants 81924 from CONACyT, IN101109 from PAPIIT and 4316 from ICyTDF. The authors kindly thank Gerardo Cedillo Valverde and Carmen Márquez for their technical assistance.
PY - 2012/4
Y1 - 2012/4
N2 - The one-step synthesis of nanodevices based on PAMAM framework for targeted cancer therapy is described. Four water-soluble nanodevices (named fractions F1 to F4) were rightly separated by size discrimination, and characterized. From biological assays of cell growth inhibition percentage, the anticancer activity of Methotrexate (chemotherapeutic drug) as part of a nanodevice, generally increases over cancer cell lines and notably, in case of human lymphocytes, the cell growth inhibition percentage decreases drastically (more than 80%), thus, the nanodevices exhibited a favorable discrimination between healthy and diseased cells. From the characterization it can be conclude that the synthesized nanodevices provide a dual scenario of drug transportation: encapsulation and conjugation.
AB - The one-step synthesis of nanodevices based on PAMAM framework for targeted cancer therapy is described. Four water-soluble nanodevices (named fractions F1 to F4) were rightly separated by size discrimination, and characterized. From biological assays of cell growth inhibition percentage, the anticancer activity of Methotrexate (chemotherapeutic drug) as part of a nanodevice, generally increases over cancer cell lines and notably, in case of human lymphocytes, the cell growth inhibition percentage decreases drastically (more than 80%), thus, the nanodevices exhibited a favorable discrimination between healthy and diseased cells. From the characterization it can be conclude that the synthesized nanodevices provide a dual scenario of drug transportation: encapsulation and conjugation.
KW - Conjugates
KW - Dendrimers
KW - Encapsulation
KW - Methotrexate
KW - Nanodevices
UR - http://www.scopus.com/inward/record.url?scp=84857917614&partnerID=8YFLogxK
U2 - 10.1016/j.bioorg.2012.01.002
DO - 10.1016/j.bioorg.2012.01.002
M3 - Artículo
SN - 0045-2068
VL - 41-42
SP - 13
EP - 21
JO - Bioorganic Chemistry
JF - Bioorganic Chemistry
ER -