TY - JOUR
T1 - Single-Chain Fragment Variable
T2 - Recent Progress in Cancer Diagnosis and Therapy
AU - Muñoz-López, Paola
AU - Ribas-Aparicio, Rosa María
AU - Becerra-Báez, Elayne Irene
AU - Fraga-Pérez, Karla
AU - Flores-Martínez, Luis Fernando
AU - Mateos-Chávez, Armando Alfredo
AU - Luria-Pérez, Rosendo
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/9
Y1 - 2022/9
N2 - Cancer remains a public health problem worldwide. Although conventional therapies have led to some excellent outcomes, some patients fail to respond to treatment, they have few therapeutic alternatives and a poor survival prognosis. Several strategies have been proposed to overcome this issue. The most recent approach is immunotherapy, particularly the use of recombinant antibodies and their derivatives, such as the single-chain fragment variable (scFv) containing the complete antigen-binding domains of a whole antibody that successfully targets tumor cells. This review describes the recent progress made with scFvs as a cancer diagnostic and therapeutic tool, with an emphasis on preclinical approaches and their potential use in clinical trials.
AB - Cancer remains a public health problem worldwide. Although conventional therapies have led to some excellent outcomes, some patients fail to respond to treatment, they have few therapeutic alternatives and a poor survival prognosis. Several strategies have been proposed to overcome this issue. The most recent approach is immunotherapy, particularly the use of recombinant antibodies and their derivatives, such as the single-chain fragment variable (scFv) containing the complete antigen-binding domains of a whole antibody that successfully targets tumor cells. This review describes the recent progress made with scFvs as a cancer diagnostic and therapeutic tool, with an emphasis on preclinical approaches and their potential use in clinical trials.
KW - cancer therapy
KW - immunotherapy
KW - single-chain fragment variable
UR - http://www.scopus.com/inward/record.url?scp=85137818434&partnerID=8YFLogxK
U2 - 10.3390/cancers14174206
DO - 10.3390/cancers14174206
M3 - Artículo de revisión
C2 - 36077739
AN - SCOPUS:85137818434
SN - 2072-6694
VL - 14
JO - Cancers
JF - Cancers
IS - 17
M1 - 4206
ER -
