TY - JOUR
T1 - Significance of CASP8AP2 and H2AFZ expression in survival and risk of relapse in children with acute lymphoblastic leukemia
AU - Juárez-Velázquez, Rocío
AU - Reyes-León, Adriana
AU - Salas-Labadía, Consuelo
AU - Rivera-Luna, Roberto
AU - Velasco-Hidalgo, Liliana
AU - López-Hernández, Gerardo
AU - López-Santiago, Norma
AU - Paredes-Aguilera, Rogelio
AU - Domínguez-López, Aarón
AU - Bernáldez, Roberto
AU - Pérez-Vera, Patricia
N1 - Publisher Copyright:
© 2014 Informa UK, Ltd.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Novel biomarkers for risk refinement and stratification in childhood acute lymphoblastic leukemia (ALL) are needed to optimize treatment results. We studied the expression of CASP8AP2 and H2AFZ associated with relapse and survival in bone marrow samples from newly diagnosed children with ALL. We found: (a) an increased risk for early relapse in those patients with low expression of CASP8AP2 (odds ratio [OR] 3.93, 95% confidence interval [CI] 1.40-11.02, p < 0.05) confirming its usefulness as a predictive risk marker, although H2AFZ did not present the same effect; (b) patients with low expressions of CASP8AP2 and H2AFZ had inferior survival rates (p < 0.001); (c) the predictive values regarding low expressions of H2AFZ and CASP8AP2 and high white blood cell count suggest that these features could help to identify more accurately patients at greater risk of relapse.
AB - Novel biomarkers for risk refinement and stratification in childhood acute lymphoblastic leukemia (ALL) are needed to optimize treatment results. We studied the expression of CASP8AP2 and H2AFZ associated with relapse and survival in bone marrow samples from newly diagnosed children with ALL. We found: (a) an increased risk for early relapse in those patients with low expression of CASP8AP2 (odds ratio [OR] 3.93, 95% confidence interval [CI] 1.40-11.02, p < 0.05) confirming its usefulness as a predictive risk marker, although H2AFZ did not present the same effect; (b) patients with low expressions of CASP8AP2 and H2AFZ had inferior survival rates (p < 0.001); (c) the predictive values regarding low expressions of H2AFZ and CASP8AP2 and high white blood cell count suggest that these features could help to identify more accurately patients at greater risk of relapse.
KW - Acute lymphoblastic leukemia
KW - CASP8AP2 expression
KW - Childhood
KW - H2AFZ expression
KW - Risk of relapse
UR - http://www.scopus.com/inward/record.url?scp=84925342802&partnerID=8YFLogxK
U2 - 10.3109/10428194.2013.878458
DO - 10.3109/10428194.2013.878458
M3 - Artículo
SN - 1042-8194
VL - 55
SP - 2305
EP - 2311
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 10
ER -