TY - JOUR
T1 - Role of LTB4 and nitric oxide in the gastroprotective effect of Prosthechea karwinskii leaves extract in the indomethacin-induced gastric injury in the rat
AU - Salinas-Nolasco, Cristina
AU - Barragán-Zarate, Gabriela Soledad
AU - Lagunez-Rivera, Luicita
AU - Solano, Rodolfo
AU - Favari, Liliana
AU - Jiménez-Andrade, Juan Miguel
AU - Chávez-Piña, Aracely Evangelina
N1 - Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2023
Y1 - 2023
N2 - Gastric injury is mainly described by inflammation of the gastric epithelium. Recently, our group of work demonstrated that Prosthechea karwinskii leaves extract induces both an in vitro antioxidative action and an in vivo gastroprotective effect in a rat. However, the molecules involved in the gastroprotective action by Prosthechea karwinskii are not known. Thus, the aim of this study is to determine whether Prosthechea karwinskii extract modifies anti-inflammatory and antioxidative biomarkers in an in vivo rat model of indomethacin-induced gastric injury. Rats were orally administered with indomethacin and Prosthechea karwinskii leaf extract. Our results suggest that the gastroprotective effect of Prosthechea karwinskii leaf extract is related to the reduction in leukocyte infiltration and antioxidative action in a model of indomethacin-induced gastric injury. Further studies are warranted to investigate the role of the compounds identified in the gastroprotective action of Prosthechea karwinskii leaves extract.
AB - Gastric injury is mainly described by inflammation of the gastric epithelium. Recently, our group of work demonstrated that Prosthechea karwinskii leaves extract induces both an in vitro antioxidative action and an in vivo gastroprotective effect in a rat. However, the molecules involved in the gastroprotective action by Prosthechea karwinskii are not known. Thus, the aim of this study is to determine whether Prosthechea karwinskii extract modifies anti-inflammatory and antioxidative biomarkers in an in vivo rat model of indomethacin-induced gastric injury. Rats were orally administered with indomethacin and Prosthechea karwinskii leaf extract. Our results suggest that the gastroprotective effect of Prosthechea karwinskii leaf extract is related to the reduction in leukocyte infiltration and antioxidative action in a model of indomethacin-induced gastric injury. Further studies are warranted to investigate the role of the compounds identified in the gastroprotective action of Prosthechea karwinskii leaves extract.
KW - Gastric injury
KW - Prosthechea karwinskii
KW - indomethacin
KW - leukotriene
KW - nitric oxide
UR - http://www.scopus.com/inward/record.url?scp=85132154448&partnerID=8YFLogxK
U2 - 10.1080/14786419.2022.2089880
DO - 10.1080/14786419.2022.2089880
M3 - Artículo
C2 - 35722687
AN - SCOPUS:85132154448
SN - 1478-6419
VL - 37
SP - 819
EP - 822
JO - Natural Product Research
JF - Natural Product Research
IS - 5
ER -