TY - JOUR
T1 - Recent advances in modified poly (lactic acid) as tissue engineering materials
AU - Castañeda-Rodríguez, Samanta
AU - González-Torres, Maykel
AU - Ribas-Aparicio, Rosa María
AU - Del Prado‑Audelo, María Luisa
AU - Leyva‑Gómez, Gerardo
AU - Gürer, Eda Sönmez
AU - Sharifi‑Rad, Javad
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - As an emerging science, tissue engineering and regenerative medicine focus on developing materials to replace, restore or improve organs or tissues and enhancing the cellular capacity to proliferate, migrate and differentiate into different cell types and specific tissues. Renewable resources have been used to develop new materials, resulting in attempts to produce various environmentally friendly biomaterials. Poly (lactic acid) (PLA) is a biopolymer known to be biodegradable and it is produced from the fermentation of carbohydrates. PLA can be combined with other polymers to produce new biomaterials with suitable physicochemical properties for tissue engineering applications. Here, the advances in modified PLA as tissue engineering materials are discussed in light of its drawbacks, such as biological inertness, low cell adhesion, and low degradation rate, and the efforts conducted to address these challenges toward the design of new enhanced alternative biomaterials.
AB - As an emerging science, tissue engineering and regenerative medicine focus on developing materials to replace, restore or improve organs or tissues and enhancing the cellular capacity to proliferate, migrate and differentiate into different cell types and specific tissues. Renewable resources have been used to develop new materials, resulting in attempts to produce various environmentally friendly biomaterials. Poly (lactic acid) (PLA) is a biopolymer known to be biodegradable and it is produced from the fermentation of carbohydrates. PLA can be combined with other polymers to produce new biomaterials with suitable physicochemical properties for tissue engineering applications. Here, the advances in modified PLA as tissue engineering materials are discussed in light of its drawbacks, such as biological inertness, low cell adhesion, and low degradation rate, and the efforts conducted to address these challenges toward the design of new enhanced alternative biomaterials.
KW - Biocomposite
KW - Biotechnology
KW - Fabrication
KW - Nanotechnology
KW - Poly (lactic acid)
KW - Tissue Engineering
UR - http://www.scopus.com/inward/record.url?scp=85150918564&partnerID=8YFLogxK
U2 - 10.1186/s13036-023-00338-8
DO - 10.1186/s13036-023-00338-8
M3 - Artículo de revisión
C2 - 36941601
AN - SCOPUS:85150918564
SN - 1754-1611
VL - 17
JO - Journal of Biological Engineering
JF - Journal of Biological Engineering
IS - 1
M1 - 21
ER -