Protein Phosphorylation in Serine Residues Correlates with Progression from Precancerous Lesions to Cervical Cancer in Mexican Patients

Juan Ramón Padilla-Mendoza, Arturo Contis-Montes De Oca, Mario Alberto Rodríguez, Mavil López-Casamichana, Jeni Bolanõs, Laura Itzel Quintas-Granados, Octavio Daniel Reyes-Hernández, Fabiola Fragozo-Sandoval, Aldo Arturo Reséndiz-Albor, Claudia Vanessa Arellano-Gutiérrez, Israel López-Reyes

    Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva


    Protein phosphorylation is a posttranslational modification that is essential for normal cellular processes; however, abnormal phosphorylation is one of the prime causes for alteration of many structural, functional, and regulatory proteins in disease conditions. In cancer, changes in the states of protein phosphorylation in tyrosine residues have been more studied than phosphorylation in threonine or serine residues, which also undergo alterations with greater predominance. In general, serine phosphorylation leads to the formation of multimolecular signaling complexes that regulate diverse biological processes, but in pathological conditions such as tumorigenesis, anomalous phosphorylation may result in the deregulation of some signaling pathways. Cervical cancer (CC), the main neoplasm associated with human papillomavirus (HPV) infection, is the fourth most frequent cancer worldwide. Persistent infection of the cervix with high-risk human papillomaviruses produces precancerous lesions starting with low-grade squamous intraepithelial lesions (LSIL), progressing to high-grade squamous intraepithelial lesions (HSIL) until CC is generated. Here, we compared the proteomic profile of phosphorylated proteins in serine residues from healthy, LSIL, HSIL, and CC samples. Our data show an increase in the number of phosphorylated proteins in serine residues as the grade of injury rises. These results provide a support for future studies focused on phosphorylated proteins and their possible correlation with the progression of cervical lesions.

    Idioma originalInglés
    Número de artículo5058928
    PublicaciónBioMed Research International
    EstadoPublicada - 1 ene 2020

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