TY - JOUR
T1 - Protective role of DDAH2 (rs805304) gene polymorphism in patients with myocardial infarction
AU - Pérez-Hernández, Nonanzit
AU - Vargas-Alarcón, Gilberto
AU - Arellano-Zapoteco, Rocio
AU - Martínez-Rodríguez, Nancy
AU - Fragoso, José Manuel
AU - Aptilon-Duque, Gad
AU - Posadas-Sánchez, Rosalinda
AU - Posadas-Romero, Carlos
AU - Juárez-Cedillo, Teresa
AU - Domínguez-López, María Lilia
AU - Rodríguez-Pérez, José Manuel
N1 - Publisher Copyright:
© 2014.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - The purpose of the present study was to establish the role of DDAH gene polymorphisms in the risk of developing myocardial infarction (MI) in a clinical cohort of Mexican patients. One polymorphism (rs1498373) in the DDAH1 and three in the DDAH2 (rs805304, rs3131383, and rs805305) genes were performed by TaqMan genotyping assays in 473 patients with MI and 447 healthy unrelated controls. Similar distribution of DDAH1 and DDAH2 polymorphisms was observed in MI patients and healthy controls. Under a recessive model adjusted for age, gender, and obesity, the rs805304 C allele was associated with decreased risk of MI (OR. = 0.70, 95% CI. = 0.51-0.96, P= 0.030). The effect of the polymorphisms on various cardiovascular risk factors was analyzed. Under a recessive model adjusted for age and gender, the DDAH2 rs805304 C allele was associated with decreased risk of obesity (OR. = 0.35, 95% CI. = 0.22-0.57, P= 0.001). The three DDAH2 polymorphisms were in strong linkage disequilibrium. Our results suggest that the rs805304 C allele was associated with decreased risk of MI and decreased risk of obesity.
AB - The purpose of the present study was to establish the role of DDAH gene polymorphisms in the risk of developing myocardial infarction (MI) in a clinical cohort of Mexican patients. One polymorphism (rs1498373) in the DDAH1 and three in the DDAH2 (rs805304, rs3131383, and rs805305) genes were performed by TaqMan genotyping assays in 473 patients with MI and 447 healthy unrelated controls. Similar distribution of DDAH1 and DDAH2 polymorphisms was observed in MI patients and healthy controls. Under a recessive model adjusted for age, gender, and obesity, the rs805304 C allele was associated with decreased risk of MI (OR. = 0.70, 95% CI. = 0.51-0.96, P= 0.030). The effect of the polymorphisms on various cardiovascular risk factors was analyzed. Under a recessive model adjusted for age and gender, the DDAH2 rs805304 C allele was associated with decreased risk of obesity (OR. = 0.35, 95% CI. = 0.22-0.57, P= 0.001). The three DDAH2 polymorphisms were in strong linkage disequilibrium. Our results suggest that the rs805304 C allele was associated with decreased risk of MI and decreased risk of obesity.
KW - Dimethylarginine dimethylaminohydrolase
KW - Haplotypes
KW - Myocardial infarction
KW - Polymorphisms
UR - http://www.scopus.com/inward/record.url?scp=84907553715&partnerID=8YFLogxK
U2 - 10.1016/j.yexmp.2014.09.015
DO - 10.1016/j.yexmp.2014.09.015
M3 - Artículo
SN - 0014-4800
VL - 97
SP - 393
EP - 398
JO - Experimental and Molecular Pathology
JF - Experimental and Molecular Pathology
IS - 3
ER -