TY - JOUR
T1 - Processing and Physicochemical Properties of Magnetite Nanoparticles Coated with Curcuma longa L. Extract
AU - Alvarado-Noguez, Margarita L.
AU - Matías-Reyes, Ana E.
AU - Pérez-González, Mario
AU - Tomás, Sergio A.
AU - Hernández-Aguilar, Claudia
AU - Domínguez-Pacheco, Flavio A.
AU - Arenas-Alatorre, Jesús A.
AU - Cruz-Orea, Alfredo
AU - Carbajal-Tinoco, Mauricio D.
AU - Galot-Linaldi, Jairo
AU - Estrada-Muñiz, Elizabet
AU - Vega-Loyo, Libia
AU - Santoyo-Salazar, Jaime
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/4
Y1 - 2023/4
N2 - In this work, Curcuma longa L. extract has been used in the synthesis and direct coating of magnetite (Fe3O4) nanoparticles ~12 nm, providing a surface layer of polyphenol groups (–OH and –COOH). This contributes to the development of nanocarriers and triggers different bio-applications. Curcuma longa L. is part of the ginger family (Zingiberaceae); the extracts of this plant contain a polyphenol structure compound, and it has an affinity to be linked to Fe ions. The nanoparticles’ magnetization obtained corresponded to close hysteresis loop Ms = 8.81 emu/g, coercive field Hc = 26.67 Oe, and low remanence energy as iron oxide superparamagnetic nanoparticles (SPIONs). Furthermore, the synthesized nanoparticles (G-M@T) showed tunable single magnetic domain interactions with uniaxial anisotropy as addressable cores at 90–180°. Surface analysis revealed characteristic peaks of Fe 2p, O 1s, and C 1s. From the last one, it was possible to obtain the C–O, C=O, –OH bonds, achieving an acceptable connection with the HepG2 cell line. The G-M@T nanoparticles do not induce cell toxicity in human peripheral blood mononuclear cells or HepG2 cells in vitro, but they can increase the mitochondrial and lysosomal activity in HepG2 cells, probably related to an apoptotic cell death induction or to a stress response due to the high concentration of iron within the cell.
AB - In this work, Curcuma longa L. extract has been used in the synthesis and direct coating of magnetite (Fe3O4) nanoparticles ~12 nm, providing a surface layer of polyphenol groups (–OH and –COOH). This contributes to the development of nanocarriers and triggers different bio-applications. Curcuma longa L. is part of the ginger family (Zingiberaceae); the extracts of this plant contain a polyphenol structure compound, and it has an affinity to be linked to Fe ions. The nanoparticles’ magnetization obtained corresponded to close hysteresis loop Ms = 8.81 emu/g, coercive field Hc = 26.67 Oe, and low remanence energy as iron oxide superparamagnetic nanoparticles (SPIONs). Furthermore, the synthesized nanoparticles (G-M@T) showed tunable single magnetic domain interactions with uniaxial anisotropy as addressable cores at 90–180°. Surface analysis revealed characteristic peaks of Fe 2p, O 1s, and C 1s. From the last one, it was possible to obtain the C–O, C=O, –OH bonds, achieving an acceptable connection with the HepG2 cell line. The G-M@T nanoparticles do not induce cell toxicity in human peripheral blood mononuclear cells or HepG2 cells in vitro, but they can increase the mitochondrial and lysosomal activity in HepG2 cells, probably related to an apoptotic cell death induction or to a stress response due to the high concentration of iron within the cell.
KW - Curcuma longaL
KW - SPIONs
KW - XPS
KW - magnetite
KW - nanoparticles
KW - single magnetic domains
UR - http://www.scopus.com/inward/record.url?scp=85156151437&partnerID=8YFLogxK
U2 - 10.3390/ma16083020
DO - 10.3390/ma16083020
M3 - Artículo
C2 - 37109857
AN - SCOPUS:85156151437
SN - 1996-1944
VL - 16
JO - Materials
JF - Materials
IS - 8
M1 - 3020
ER -