TY - JOUR
T1 - Platelet cytoskeleton and its hemostatic role
AU - Cerecedo, Doris
PY - 2013/12
Y1 - 2013/12
N2 - Upon vascular injury, platelets adhere to the exposed extracellular matrix, which triggers the platelet activation and aggregation to form a hemostatic plug to seal the wound. All of these events involve dramatic changes in shape because of the cytoskeleton reorganization. The versatility of the cytoskeleton's main elements depends on the biochemical nature of the elements, as well as on the associated proteins that confer multiple functions within the cell. The list of these associated proteins grows actively, increasing our knowledge concerning the complexity of platelet cytoskeleton machinery. The present review evidences the recently described platelet proteins that promote characteristic modifications in their cytoskeleton organization, with special focus on the dystrophin-glycoprotein complex.
AB - Upon vascular injury, platelets adhere to the exposed extracellular matrix, which triggers the platelet activation and aggregation to form a hemostatic plug to seal the wound. All of these events involve dramatic changes in shape because of the cytoskeleton reorganization. The versatility of the cytoskeleton's main elements depends on the biochemical nature of the elements, as well as on the associated proteins that confer multiple functions within the cell. The list of these associated proteins grows actively, increasing our knowledge concerning the complexity of platelet cytoskeleton machinery. The present review evidences the recently described platelet proteins that promote characteristic modifications in their cytoskeleton organization, with special focus on the dystrophin-glycoprotein complex.
KW - adhered platelets
KW - dystroglycan
KW - dystrophins
KW - focal adhesions
UR - http://www.scopus.com/inward/record.url?scp=84888132486&partnerID=8YFLogxK
U2 - 10.1097/MBC.0b013e328364c379
DO - 10.1097/MBC.0b013e328364c379
M3 - Artículo de revisión
SN - 0957-5235
VL - 24
SP - 798
EP - 808
JO - Blood Coagulation and Fibrinolysis
JF - Blood Coagulation and Fibrinolysis
IS - 8
ER -