TY - JOUR
T1 - Phycobiliproteins from Pseudanabaena tenuis rich in c-phycoerythrin protect against HgCl2-caused oxidative stress and cellular damage in the kidney
AU - Cano-Europa, Edgar
AU - Ortiz-Butrón, Rocio
AU - Gallardo-Casas, Carlos Angel
AU - Blas-Valdivia, Vanessa
AU - Pineda-Reynoso, Marisol
AU - Olvera-Ramírez, Roxana
AU - Franco-Colin, Margarita
PY - 2010
Y1 - 2010
N2 - Our objective was to study if the phycobiliproteins of the cyanobacterium Pseudanabanea tenuis rich in phycoerythrin protect renal cells against mercury-caused oxidative stress and cellular damage in the kidney. We used 40 male mice that were assigned into five groups: a control group that received phosphate buffer (PB) and saline and four treatment groups which received either PB+HgCl2, PB+phycobiliproteins, or HgCl2+phycobiliproteins. The kidneys of the mice were used to determine lipid peroxidation and quantification of reactive oxygen species, oxidized glutathione, and peroxidase activities (catalase and glutathione peroxidase) and were also examined histologically. Our results demonstrated that HgCl2 causes oxidative stress and cellular damage and that all doses of phycobiliproteins prevented the increase of oxidative markers and partially protected against HgCl2-caused cell damage. This is the first report which applied phycobiliproteins of P. tenuis rich in c-phycoerythrin, like antioxidants against mercury chloride-caused oxidative stress and renal damage.
AB - Our objective was to study if the phycobiliproteins of the cyanobacterium Pseudanabanea tenuis rich in phycoerythrin protect renal cells against mercury-caused oxidative stress and cellular damage in the kidney. We used 40 male mice that were assigned into five groups: a control group that received phosphate buffer (PB) and saline and four treatment groups which received either PB+HgCl2, PB+phycobiliproteins, or HgCl2+phycobiliproteins. The kidneys of the mice were used to determine lipid peroxidation and quantification of reactive oxygen species, oxidized glutathione, and peroxidase activities (catalase and glutathione peroxidase) and were also examined histologically. Our results demonstrated that HgCl2 causes oxidative stress and cellular damage and that all doses of phycobiliproteins prevented the increase of oxidative markers and partially protected against HgCl2-caused cell damage. This is the first report which applied phycobiliproteins of P. tenuis rich in c-phycoerythrin, like antioxidants against mercury chloride-caused oxidative stress and renal damage.
KW - Environmental health
KW - Mechanism of action
KW - Mercury
KW - Phycobiliproteins
KW - Pollutants
KW - Renal damage
UR - http://www.scopus.com/inward/record.url?scp=77954424253&partnerID=8YFLogxK
U2 - 10.1007/s10811-009-9484-z
DO - 10.1007/s10811-009-9484-z
M3 - Artículo
SN - 0921-8971
VL - 22
SP - 495
EP - 501
JO - Journal of Applied Phycology
JF - Journal of Applied Phycology
IS - 4
ER -