TY - JOUR
T1 - Photoacoustic Spectroscopy to determine in vitro the non radiative relaxation time of protoporphyrin IX solution containing gold metallic nanoparticles
AU - Pérez, J. L.Jiménez
AU - Cruz-Orea, A.
AU - Ramón-Gallegos, E.
AU - Fuentes, R. Gutierrez
AU - Ramirez, J. F.Sanchez
N1 - Funding Information:
We would like to thank Conacyt, COFAA and CGPI-IPN, México for their partial financial support.
PY - 2008/1
Y1 - 2008/1
N2 - In order to compare the non radiative relaxation time (NRRT) between standard protoporphyrin IX (PpIX) and protoporphyrin PpIX(1) solution containing gold metallic nanoparticles, we measured the photoacoustic spectroscopy (PAS) signal phase to determine, for each solution, the NRRT by using the Rosencwaig-Gesho theory, modified to include the effect of a finite non radiative deexcitation time. A NRRT average value, obtained for each solution, is reported and compared with some NRRT of triplet states reported in the literature for molecules with the same tetrapyrrolic structure. In the study was used PpIX disodium salt (DS) solution of 25% HCL. From each solution it was obtained its optical absorption spectrum, by using a UV-Vis spectrophotometer. After this, in the maximum observed optical absorption peak (404 nm), it was obtained the Photoacoustic (PA) signal phase as a function of the light modulation frequency, from 17 to 80 Hz. Our investigations are devoted to the improvement of the thermal treatments of drugs for medical applications.
AB - In order to compare the non radiative relaxation time (NRRT) between standard protoporphyrin IX (PpIX) and protoporphyrin PpIX(1) solution containing gold metallic nanoparticles, we measured the photoacoustic spectroscopy (PAS) signal phase to determine, for each solution, the NRRT by using the Rosencwaig-Gesho theory, modified to include the effect of a finite non radiative deexcitation time. A NRRT average value, obtained for each solution, is reported and compared with some NRRT of triplet states reported in the literature for molecules with the same tetrapyrrolic structure. In the study was used PpIX disodium salt (DS) solution of 25% HCL. From each solution it was obtained its optical absorption spectrum, by using a UV-Vis spectrophotometer. After this, in the maximum observed optical absorption peak (404 nm), it was obtained the Photoacoustic (PA) signal phase as a function of the light modulation frequency, from 17 to 80 Hz. Our investigations are devoted to the improvement of the thermal treatments of drugs for medical applications.
UR - http://www.scopus.com/inward/record.url?scp=40949095355&partnerID=8YFLogxK
U2 - 10.1140/epjst/e2008-00460-2
DO - 10.1140/epjst/e2008-00460-2
M3 - Artículo
AN - SCOPUS:40949095355
SN - 1951-6355
VL - 153
SP - 353
EP - 356
JO - European Physical Journal: Special Topics
JF - European Physical Journal: Special Topics
IS - 1
ER -