Parasitaemia levels in Plasmodium chabaudi infected-mice modify IFN-γ and IL-10 expression after a homologous or heterologous challenge

Maribel Aguilar-Medina, R. Ramos-Payán, E. Arámbula-Meraz, L. Sánchez-Torres, L. Favila-Castillo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

CB6F1 mice infected with the nonlethal Plasmodium chabaudi chabaudi AS suffer parasitaemia levels up to 40% (full parasitaemia, FP) and develop both homologous and heterologous (against the lethal Plasmodium yoelii 17XL) protective immunity. However, if mice are treated with anti-malarial drug when parasitaemia is below 10% (low parasitaemia, LP), they only develop homologous immunity. For the better understanding of this interesting dissociation related to the degree of parasitaemia, in this work, we studied the genetic expression of some cytokines. We found that during primary parasitaemia both FP and LP mice showed at first a TNF-α, IL-2 and IFN-γ response which is followed by an IL-4 and IL-10 response. When FP and LP mice were challenged with either the homologous (FP + AS and LP + AS mice) or the heterologous parasite (FP + 17XL and LP + 17XL mice), we observed that LP + 17XL mice, which failed to develop heterologous immunity and succumbed to the challenge, showed a stronger IFN-γ and a weaker IL-10 expression than FP + 17XL mice, which developed heterologous immunity and survived the challenge. The importance and the possible implications of these findings are discussed.

Idioma originalInglés
Páginas (desde-hasta)267-274
Número de páginas8
PublicaciónParasite Immunology
Volumen32
N.º4
DOI
EstadoPublicada - abr. 2010

Huella

Profundice en los temas de investigación de 'Parasitaemia levels in Plasmodium chabaudi infected-mice modify IFN-γ and IL-10 expression after a homologous or heterologous challenge'. En conjunto forman una huella única.

Citar esto