Resumen
Alkylation of benzyl vinyl carbamate and propene with the anions of diethyl methylmalonate or dimethyl malonate in the presence of palladium(II) chloride, followed by cross-coupling or carbonylative cross-coupling with organostannanes, effected an overall dialkylation or alkylation/acylation of the monoolefin substrate. Complete control of stereochemistry in this palladium(II)-assisted reaction was observed using optically active ene carbamates affording β-amino-unsaturated keto esters in good chemical yields and excellent optical purity.
Idioma original | Inglés |
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Páginas (desde-hasta) | 5666-5671 |
Número de páginas | 6 |
Publicación | Journal of Organic Chemistry |
Volumen | 56 |
N.º | 19 |
DOI | |
Estado | Publicada - 1 sep. 1991 |
Publicado de forma externa | Sí |