TY - JOUR
T1 - Overview of Staphylococcus epidermidis cell wall-anchored proteins
T2 - potential targets to inhibit biofilm formation
AU - Ortega-Peña, Silvestre
AU - Martínez-García, Sergio
AU - Rodríguez-Martínez, Sandra
AU - Cancino-Diaz, Mario E.
AU - Cancino-Diaz, Juan C.
N1 - Publisher Copyright:
© 2019, Springer Nature B.V.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Currently, the treatment of infections by Staphylococcus epidermidis (S. epidermidis) represents a challenge because some strains have multidrug-resistance to antimicrobial products (antibiotic and biocides) and can produce biofilms. These biofilms protect bacterial cells from both antimicrobials and the host immune response. Therefore, it is crucial to encourage research on the development of new treatments. One method is immunotherapy, targeting components of S. epidermidis, such as S. epidermidis surface (Ses) proteins. Ses is expressed constitutively in most strains, and they participate in biofilm formation. This review is an update on Ses, regarding their structure, biological function, their relationship with S. epidermidis biofilm formation, and its possible role as therapeutic targets to develop immunotherapeutic treatments to prevent infections by S. epidermidis.
AB - Currently, the treatment of infections by Staphylococcus epidermidis (S. epidermidis) represents a challenge because some strains have multidrug-resistance to antimicrobial products (antibiotic and biocides) and can produce biofilms. These biofilms protect bacterial cells from both antimicrobials and the host immune response. Therefore, it is crucial to encourage research on the development of new treatments. One method is immunotherapy, targeting components of S. epidermidis, such as S. epidermidis surface (Ses) proteins. Ses is expressed constitutively in most strains, and they participate in biofilm formation. This review is an update on Ses, regarding their structure, biological function, their relationship with S. epidermidis biofilm formation, and its possible role as therapeutic targets to develop immunotherapeutic treatments to prevent infections by S. epidermidis.
KW - Biofilm
KW - Immunotherapy
KW - Ses
KW - Staphylococcus epidermidis
UR - http://www.scopus.com/inward/record.url?scp=85074043494&partnerID=8YFLogxK
U2 - 10.1007/s11033-019-05139-1
DO - 10.1007/s11033-019-05139-1
M3 - Artículo de revisión
C2 - 31642039
AN - SCOPUS:85074043494
SN - 0301-4851
VL - 47
SP - 771
EP - 784
JO - Molecular Biology Reports
JF - Molecular Biology Reports
IS - 1
ER -