Outside-binding site mutations modify the active site's shapes in neuraminidase from influenza A H1N1

Medicina y ciencias biológicas

• influenza A virus NA protein 100%
• Oseltamivir 65%
• Neuraminidase 63%
• Catalytic Domain 50%
• Binding Sites 43%
• Mutation 31%
• poly(tetramethylene succinate-co-tetramethylene adipate) 29%
• Molecular Dynamics Simulation 17%
• Pandemics 8%
• Human Influenza 7%
• Ligands 5%
• Viruses 5%
• Drug Therapy 4%

Ingeniería y ciencia de los materiales

• Binding sites 78%
• Free energy 44%
• Molecular dynamics 41%
• Computer simulation 30%
• Drug therapy 29%
• Ligands 24%
• Viruses 21%
• Inspection 14%

Química

• Oseltamivir 87%
• Mutation 47%
• Shape 36%
• Gibbs Free Energy 21%
• Molecular Dynamics 20%
• Simulation 17%
• Resistance 17%
• Calorific Value 14%
• Drug 7%
• Ligand 6%