TY - JOUR
T1 - Optimization of the conditions for the elaboration of chitosan nanoparticles charged with alpha lipoic acid, ascorbic acid and Alpha-Tocopherol
AU - Rosales-Martínez, P.
AU - García-Pinilla, S.
AU - Arroyo-Maya, I. J.
AU - Hernández-Sánchez, H.
AU - Cornejo-Mazón, M.
N1 - Publisher Copyright:
© 2017, Universidad Autonoma Metropolitana Iztapalapa. All rights reserved.
PY - 2017
Y1 - 2017
N2 - Advances in nano materials with antioxidant activity are considered as an emerging subject in food and pharmaceutical industries. The objective of the present work was to propose and optimize the necessary conditions for the formation of chitosan nanoparticles containing α-Lipoic acid, α-Tocopherol and ascorbic acid, as well as to determine the physicochemical and morphological properties of such particles. The determination of antioxidant activity was performed by the DPPH, FRAP and ABTS for the antioxidants mixture design in such a way that the mixture presenting the highest antioxidant activity was used in the preparation of nanoparticles that were analysed in terms of Z Potential, size and distribution, and observed in terms TEM. The design of ternary mixtures of ascorbic acid/α-Lipoic acid/α-Tocopherol showed the higher antioxidant activity with DPPH technique with the proportions: 250 mg/667 mg/183 mg respectively. Z Potential showed higher values at low pH and TPP and Tween 80 positively aαected in this parameter. Size and distribution of nanoparticles, the smaller size was obtained using TPP and Tween 80 with and without the presence of the antioxidant mixture, between 52 to 260 nm.
AB - Advances in nano materials with antioxidant activity are considered as an emerging subject in food and pharmaceutical industries. The objective of the present work was to propose and optimize the necessary conditions for the formation of chitosan nanoparticles containing α-Lipoic acid, α-Tocopherol and ascorbic acid, as well as to determine the physicochemical and morphological properties of such particles. The determination of antioxidant activity was performed by the DPPH, FRAP and ABTS for the antioxidants mixture design in such a way that the mixture presenting the highest antioxidant activity was used in the preparation of nanoparticles that were analysed in terms of Z Potential, size and distribution, and observed in terms TEM. The design of ternary mixtures of ascorbic acid/α-Lipoic acid/α-Tocopherol showed the higher antioxidant activity with DPPH technique with the proportions: 250 mg/667 mg/183 mg respectively. Z Potential showed higher values at low pH and TPP and Tween 80 positively aαected in this parameter. Size and distribution of nanoparticles, the smaller size was obtained using TPP and Tween 80 with and without the presence of the antioxidant mixture, between 52 to 260 nm.
KW - Antioxidant activity
KW - Ascorbic acid
KW - Chitosan
KW - Nanoparticles
KW - α-lipoic acid
KW - α-tocopherol
UR - http://www.scopus.com/inward/record.url?scp=85019144070&partnerID=8YFLogxK
M3 - Artículo
SN - 1665-2738
VL - 16
SP - 319
EP - 335
JO - Revista Mexicana de Ingeniera Quimica
JF - Revista Mexicana de Ingeniera Quimica
IS - 1
ER -