TY - JOUR
T1 - New dendritic porphyrins
T2 - Synthesis, spectroscopic and antibacterial evaluation
AU - Ramírez, Raquel Eunice Hernández
AU - Militello, M. Paula
AU - Arbeloa, Ernesto M.
AU - Lijanova, Irina V.
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/5/15
Y1 - 2023/5/15
N2 - In this work, a new porphyrin-dendrimer (Pf-PPI) was synthesized, which can form complex Ag+ leading to a Pf-PPI-Ag+ stable compound. The molecular structure of the dendrimers was characterized by 1H NMR and 13C NMR, FT-IR, TGA and UV–vis. The metal complexation capacity of dendritic nanostructures was evaluated using filtration followed by atomic absorption, and the binding sites were elucidated by FT-IR spectrometry and TGA analysis. The results show that the functional groups in dendrimer branches are involved in the retention rate of cations. Transient studies proved good capacity for singlet oxygen generation even in the presence of the cation, showing that both complexing and sensitizing properties are compatible with each other. The antibacterial effect of the compounds on E. coli was also evaluated. Although some dark toxicity was observed, a complete and faster bacterial inactivation was recorded under visible light irradiation, demonstrating high photodynamic efficiency of the tested compounds.
AB - In this work, a new porphyrin-dendrimer (Pf-PPI) was synthesized, which can form complex Ag+ leading to a Pf-PPI-Ag+ stable compound. The molecular structure of the dendrimers was characterized by 1H NMR and 13C NMR, FT-IR, TGA and UV–vis. The metal complexation capacity of dendritic nanostructures was evaluated using filtration followed by atomic absorption, and the binding sites were elucidated by FT-IR spectrometry and TGA analysis. The results show that the functional groups in dendrimer branches are involved in the retention rate of cations. Transient studies proved good capacity for singlet oxygen generation even in the presence of the cation, showing that both complexing and sensitizing properties are compatible with each other. The antibacterial effect of the compounds on E. coli was also evaluated. Although some dark toxicity was observed, a complete and faster bacterial inactivation was recorded under visible light irradiation, demonstrating high photodynamic efficiency of the tested compounds.
KW - Infrared spectrometry
KW - Metal complex
KW - Photodynamic inactivation
KW - Porphyrin dendrimers
KW - Singlet oxygen
UR - http://www.scopus.com/inward/record.url?scp=85147605163&partnerID=8YFLogxK
U2 - 10.1016/j.molstruc.2023.135034
DO - 10.1016/j.molstruc.2023.135034
M3 - Artículo
AN - SCOPUS:85147605163
SN - 0022-2860
VL - 1280
JO - Journal of Molecular Structure
JF - Journal of Molecular Structure
M1 - 135034
ER -